多杀菌素A衍生物的合成及其生物活性研究  

Study on the Synthesis and Insecticidal Activity of Spinosyn A Derivatives

作　　者：张凯 李加荣 温都苏 刘洪林[2] 王海邮 阿拉木斯[2] Zhang Kai;Li Jiarong;Wen Dusu;Liu Honglin;Wang Haiyou;A Lamusi(School of Chemistry and Chemical Engineering,Beijing Institute of Technology,Beijing 100081;Institute of Grassland Research of Chinese Academy of Agricultural Sciences,Hohhot 010000)

机构地区：[1]北京理工大学化学与化工学院,北京100081 [2]中国农业科学院草原研究所,呼和浩特010000

出　　处：《有机化学》2018年第12期3363-3372,共10页Chinese Journal of Organic Chemistry

基　　金：国家自然基金基金(N0.41471198)资助项目.

摘　　要：多杀菌素(Spinosyns)是一类由放线菌刺糖多孢菌发酵产生的新型生物杀虫剂,因其具有广谱高效、对环境和非靶标动物毒性小等优点,已经被广泛应用于农业的虫害防治中.为了寻找更高效的杀虫剂,合成了一系列多杀菌素A C-17位不同取代基的衍生物,并测定了对小菜蛾的杀虫活性.所合成的衍生物均对小菜蛾表现出不错的杀虫活性.Spinosyns are a novel kind of biopesticide produced by Saccharopolyspora spinosa. Spinosyns have been widely applied in pest control because of their broad insecticidal spectrum, high insecticidal activity, low environmental impact, and low toxicity. To identify spinosyn compounds with improved insecticidal activity, a series of D-forosamine replacement derivatives of spinosyn A were synthesized. The insecticidal activities of the synthetic derivatives were evaluated against 3rd-instar larvae of Plutella xylostella. All derivatives exhibited good insecticidal activity to P. xylostella.

关 键 词：天然产物 多杀菌素A 半合成衍生物 杀虫活性 

分 类 号：TQ453[化学工程—农药化工]