大气压等离子体作用于细胞产生电场效应的数值模拟研究  

Numerical study on distribution of electric fields in cells induced by atmospheric helium plasmas

作　　者：刘雨 高皓天 赵彤[1] 邹亮[1] 张远涛[1] LIU Yu;GAO HaoTian;ZHAO Tong;ZOU Liang;ZHANG YuanTao(School of Electrical Engineering,Shandong University,Jinan 250061,China;School of Electrical Engineering,Chongqing University,Chongqing 400044,China;Huzhou Power Supply Company of State Grid of Zhejiang Electric Power Company,Huzhou 313000,China)

机构地区：[1]山东大学电气工程学院,济南250061 [2]国家电网浙江省电力有限公司湖州供电公司,湖州313000 [3]重庆大学电气工程学院,重庆400044

出　　处：《中国科学：物理学、力学、天文学》2019年第1期49-61,共13页Scientia Sinica Physica,Mechanica & Astronomica

基　　金：国家自然科学基金(批准号:11675095);山东大学基本科研业务费(批准号:2017JC017)资助项目

摘　　要：近年来,随着大气压等离子体技术的发展,等离子体医学作为新兴的交叉学科逐渐发展起来,大量实验研究表明,等离子体对生物组织会产生各种显著的效应,但人们始终缺乏对等离子体与生物组织相互作用内在机理的深入认识.本文从描述大气压等离子体的流体模型出发,耦合描述细胞电学特性的细胞介电模型,研究了正弦电压驱动的介质阻挡放电产生的大气压氦等离子体作用于细胞时,细胞中电场的分布与演化.计算结果表明,细胞膜电压占细胞总电压的主要部分,内膜电压远小于外模电压,肿瘤细胞的跨膜电压明显大于正常细胞的跨膜电压,且内膜电压只在放电过程中数值较大,而外膜电压则在放电后始终保持较大的数值.基于模拟结果,本文还讨论了放电参数对跨膜电压的影响.目前,有关等离子体医学的理论研究还较少,本文的计算将为研究大气压等离子体对细胞的电磁效应机理提供有益的探索.In recent years, plasma medicine has attracted more and more attentions with the fast development of atmospheric plasmas technology. The experimental measurements have definitely shown some positive effects on the biological tissue and materials, however, the mechanisms of interactions between atmospheric plasma and cells are still unknown. In this paper, we coupled the fluid model and multi-layer dielectric of spherical cell to investigate the temporal-spatial distribution of electric fields in the cells induced by the atmospheric plasmas generated by dielectric barrier discharges.From the simulation data, the voltage on the cell almost totally drops on plasma membrane and the voltage on the plasma membrane is much larger than that of normal cells. On the other hand, both the transmembrane potentials of inner and outer membrane rise very fast during the process of ignition, then the former drops quickly after the breakdown, but the later sustains at a relatively large value until the next breakdown event. The influences on the voltage distribution in cell of applied voltage and excitation frequency are also discussed based on the simulation data. At present, the numerical investigations on the interaction of plasma and cells still need to be greatly developed, and the given simulation in this work will show some insights to the further theoretical study.

关 键 词：大气压等离子体 介质阻挡放电 细胞介电模型 跨膜电压 数值模拟 

分 类 号：Q27[生物学—细胞生物学]