生物碱Peduncularine的合成策略和方法  

Methods and Strategies for the Synthesis of Peduncularine

作　　者：章玉平 田学超 张岩[2] 洪然[2] 黄莎华 Zhang Yuping;Tian Xuechao;Zhang Yan;Hong Ran;Huang Shahua(School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418;CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)

机构地区：[1]上海应用技术大学化学与环境工程学院,上海201418 [2]中国科学院上海有机化学研究所中国科学院天然产物有机合成化学重点实验室分子合成卓越创新中心,上海200032

出　　处：《有机化学》2019年第1期47-58,共12页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21402121);上海应用技术大学协同创新计划(No.XTCX2015-16)项目资助~~

摘　　要：(-)-Peduncularine是从塔斯玛尼亚灌木Aristotelia peduncularis中分离得到的生物碱,含吲哚结构单元且含有高张力的6-氮杂双环[3.2.1]辛烷核心骨架.由于其独特的结构,受到合成化学家的极大关注.目前,已有多个课题组对其展开了全合成研究.本文将介绍近年来不同研究小组所发展peduncularine的合成策略,对于药物合成研究中类似特殊环系的构建提供借鉴.(-)-Peduncularine is the principal alkaloid isolated from Tasmanian shrub Aristotelia peduncularis. Due to its unusual 6-azabicyclo[3.2.1]octane core, the indole alkaloid was received numerous attention from the synthetic community and several innovative synthetic strategies have been developed. In this minireview, the synthetic efforts of peduncularine are summarized as inspiration for future development of medicinally interesting derivatives.

关 键 词：6-氮杂双环[3.2.1]辛烷 成环反应 吲哚生物碱 peduncularine 全合成 

分 类 号：TQ463[化学工程—制药化工]