PhI（OAc）2参与的β-酮酸酯及β-酮酰胺亲核氟化反应  

Fluorination of β-Ketoesters and β-Ketoamides Based on PhI（OAc）2

作　　者：吴文胜 袁航 黄高魁 蒋春辉 陆鸿飞 Wu Wensheng;Yuan Hang;Huang Gaokui;Jiang Chunhui;Lu Hongfei(School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003)

机构地区：[1]江苏科技大学环境与化学工程学院

出　　处：《有机化学》2019年第1期137-143,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21402067);江苏省自然科学基金(No.BK20170569);江苏省高校自然科学基金(No.17KJB150013)资助项目~~

摘　　要：报道了一种构建含氟的β-酮酸酯及β-酮酰胺的亲核氟化反应.该反应采用PhI(OAc)2为氧化剂、3HF·Et3N为氟化试剂,在室温下反应30min高效构建一系列含有季碳中心的含氟化合物.与传统的亲电氟化反应相比,该方法具有无金属参与、反应时间短、反应条件简单、反应收率高等优点.Herein, a nucleophilic fluorination reaction to construct fluorine-containing β-ketoesters and β-ketoamides is reported. The reaction uses PhI(OAc)2 as oxidant and 3HF·Et3N as fluorinating reagent. It can effectively build a series of fluorochemical compounds containing quaternary carbon center under room temperature reaction conditions for 30 min. Compared with the traditional electrophilic fluorination reaction, this method has the advantages of no metal participation, short reaction time, simple reaction conditions and high reaction yield.

关 键 词：高价碘 Β-酮酸酯 β-酮酰胺 亲核氟化反应 

分 类 号：O621.25[理学—有机化学]