镍催化的偕二氟芳基乙烯与有机锌交叉偶联反应立体选择性合成(Z)-单氟烯烃  

Stereoselective Synthesis of Z-Fluorostyrene Derivatives via Nickel-Catalyzed Cross-Coupling of gem-Difluorostyrenes with Organozinc Reagents

作　　者：张娟[1] 王碧云 刘熠森 曹松[1] Zhang Juan;Wang Biyun;Liu Yisen;Cao Song(Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology(ECUST), Shanghai 200237)

机构地区：[1]上海市化学生物学(芳香杂环)重点实验室华东理工大学药学院

出　　处：《有机化学》2019年第1期249-256,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21472043,21272070)资助项目~~

摘　　要：报道了在NiCl2(dppp)催化和氯化锂促进下,室温下将偕二氟芳基乙烯与有机锌试剂进行交叉偶联反应,合成一系列(Z)-单氟烯烃的方法.该方法具有反应条件温和、操作简单、官能团兼容性较好、立体选择性出色等优点.An efficient method for the synthesis of various Z-fluorostyrene derivatives via nickel-catalyzed cross-coupling of gem-difluorostyrenes with organozinc reagents with the assistance of LiCl was developed. The reaction proceeds efficiently under mild condition, affording monofluoroalkenes in moderate to good yields. This novel method exhibits good functional group compatibility and excellent stereoselectivity.

关 键 词：偕二氟芳基乙烯 镍催化 有机锌 单氟烯烃 

分 类 号：O621.251[理学—有机化学] O623.22[理学—化学]