新型眼底影像检查技术在糖尿病视网膜病变诊断中的应用  

Application of new fundus imaging in diabetic retinopathy

作　　者：李晓莉 孟倩丽 谢洁 陈湘婷 黄天 Li Xiaoli;Meng Qianli;Xie Jie;Chen Xiangting;Huang Tian(Department of Ophthalmology, Guangdong General Hospital, Guangdong Eye Institute, Guangdong Academy of Medical Sciences, 515100 Guangzhou, China)

机构地区：[1]广东省人民医院(广东省医学科学院)眼科,广州515100

出　　处：《中华眼底病杂志》2019年第1期90-94,共5页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金 (81371031);广东省自然科学基金 (2017A030313609);广东省医学科学技术研究基金 (A2018401).

摘　　要：糖尿病视网膜病变(DR)是导致糖尿病患者视力损伤和失明的主要原因,寻求更简便、安全、无创、高效的诊查及监控方法尤为重要。近年推出的多种新型眼底影像检查技术在DR的早期诊断、指导治疗和随访监测中显示出了独特的优势。广角激光扫描眼底成像系统具有免散瞳、快速、无创、成像范围广等特点,包括广角眼底照相、超广角FFA、广角FAF等多种激光扫描模式,可通过不同波长成像定位病变位置。多光谱眼底分层成像系统可识别DR的微动脉瘤、视网膜出血、渗出等,因其无创、方便、快捷,已逐渐用于DR的筛查、诊断和随访。OCT血管成像技术可对黄斑中心凹无血管区面积、黄斑血流密度等进行定量检测,为临床提供多元化的DR诊断依据和评估手段。这些新型眼底影像检查技术的不断完善将对建立个性化的DR评估体系提供重要的技术支持。Diabetic retinopathy (DR) is one of the most common causes of visual impairment and blindness in diabetic patients. It is particularly important to set up simpler, safer, non-invasive and highly effective methods for diagnosis as well as monitoring DR. A variety of new fundus imaging techniques show great advantages in early diagnosis, treatment and monitoring of DR in recent years. The main characteristics of wide-field scanning laser imaging system is achieving a large range of retinal image in a single photograph and without mydriasis. It provides several options for color images, FFA and FAF, which satisfy to detect the retina, choroid and vascular structure. Multi spectral fundus imaging system is suitable for DR screening, because it is able to recognize the typical characteristics of DR, such as microaneurysms, hemorrhage and exudation, and is non-invasive and convenient. OCT angiography is a quantitative examination that provides foveal avascular zone area, macular blood flow density, which provides strong evidence for DR diagnosis. The improvement of these new techniques will help us to build up a personalized evaluation system of DR.

关 键 词：糖尿病视网膜病变/诊断 检眼镜检查 显微镜检查 共焦 体层摄影术 光学相干 彩色眼底照相 

分 类 号：R587.2[医药卫生—内分泌]