超滤-质谱技术在中药活性成分筛选中的应用进展  

Application of ultrafiltration-mass spectrometry in screening of active components in Chinese meteria medica

作　　者：张慧[1] 徐聪[1] 吴媛媛 田清华 张亚 颜继忠[1] ZHANG Hui;XU Cong;WU Yuan-yuan;TIAN Qing-hua;ZHANG Ya;YAN Ji-zhong(Zhejiang University of Technology,Hangzhou 310014,China)

机构地区：[1]浙江工业大学,浙江杭州310014

出　　处：《中草药》2018年第23期5712-5718,共7页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81603249);中国博士后科学基金面上资助(2018M632507)

摘　　要：超滤-质谱技术作为一种新兴的药物活性成分筛选方法,具有操作简单、分析速度快、特异性强、高通量等特点,在天然活性成分筛选中发挥着重要作用。以不同疾病相关的靶标为切入点,综述了近年来超滤-质谱技术在中药提取物中快速筛选天然活性成分的应用进展。对超滤-质谱技术存在的一些不足和未来的发展进行总结和展望,以期为相关研究提供一定的借鉴。As an emerging method for active ingredients screening, ultrafiltration-mass spectrometry(UF-MS) has the characteristics of simple operation, fast analysis, strong specificity, and high throughput. It plays an important role in the screening of natural active ingredients. In this paper, using the different disease-related targets as key point, the application of UF-MS in the rapid screening of natural active ingredients in Chinese meteria medica extracts were reviewed. Combining the practice of the research group for many years, the deficiencies and the development of the UF-MS technology were prospected to provide a reference for related research.

关 键 词：超滤-质谱技术 中药 高通量 天然活性成分 靶标 

分 类 号：R286.0[医药卫生—中药学]