磁应答型药物递送载体的设计与构建  

Design and Fabrication of Magnetically Responsive Drug Delivery Carriers

作　　者：毕洪梅[1] 韩晓军 Hongmei Bi;Xiaojun Han(College of Science,Heilongjiang Bayi Agricultural University,Daqing 163319,China;State Key Laboratory of Urban Water Resource and Environment,School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin 150001,China)

机构地区：[1]黑龙江八一农垦大学理学院,大庆163319 [2]城市水资源与水环境国家重点实验室哈尔滨工业大学化工与化学学院,哈尔滨150001

出　　处：《化学进展》2018年第12期1920-1929,共10页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21503072;21773050);学成引进人才项目(No.XDB-2017-19);国家留学基金委项目(No.20163035)资助~~

摘　　要：复合磁性生物材料的发展和应用已引起生物医学领域的极大关注。磁性纳米粒子因其易功能化而具有靶向药物传递、可控药物释放及磁成像特性逐渐成为药物传递和新型诊疗领域最有前途的材料之一。基于磁性纳米粒子或掺杂的铁氧化物构建的远程触发磁性载药递送系统,有望实现在运输过程中携载药物不泄露的情况下,提高药物递送效率且对病灶周围的健康细胞无毒或低毒性。为构建理想的可控靶向磁性药物递送系统,多种材料或配体可以与磁性纳米粒子复合来构建更安全有效的磁性药物递送系统。一些生物分子、聚合物及天然产物等通过与磁性纳米粒子相结合,构建出可用于药物传递且具有独特性质的磁性复合新材料。迄今为止,具有磁场应答能力的磁性药物递送载体已经在远程控制药物释放领域得到了长足发展。本文总结了近年来磁性药物递送载体作为远程控制治疗体系在设计与构建上的研究进展。重点关注了磷脂分子、聚合物、多孔微纳米材料以及天然产物等与其构建的复合材料,并对当前磁性复合特定给药载体的优点、局限及发展前景等做了简要阐述。Development and application of hybrid magnetic biomaterials has been attracting great attention in biomedical applications. Magnetic nanoparticles(MNPs) have emerged as a promising theranostic tool for diagnostic imaging, drug delivery and novel therapeutics because of their functionalization, targeted delivery, controllable drug release and image-guided capabilities. Remotely triggered magnetic drug delivery systems based on MNPs or doped iron oxides can enhance the drug delivery efficiency to the cancerous regions with low toxicity or without toxicity to the surrounding healthy cells. In order to fabricate safer and more effective magnetic drug delivery systems, different materials or ligands such as biomolecules, polymers even natural extractive are combined with MNPs by this hybrid approach, which has created entirely new advanced compositions with truly unique properties for drug delivery. So far, the responsive nano-structured magnetic drug delivery carriers have been extensively explored for remotely controlled drug release although there are still some difficulties and challenges. In this review, we summarize the recent advances in the design and fabrication of hybrid magnetic drug delivery carriers as remotely controlled therapeutic systems with a focus on the materials for delivery carriers fabrication including phospholipid molecules, polymers, mesoporous micro-nanomaterials, natural extractive, etc. In addition, the advantages, limits and prospects of current hybrid targeted magnetic drug delivery carriers are also briefly summarized.

关 键 词：磁性药物递送载体 磁性纳米粒子 磷脂 聚合物 多孔微纳米材料 天然提取物 

分 类 号：O648[理学—物理化学] TB34[理学—化学]