补肾调经膏方治疗肾虚型卵巢早衰的疗效及对性激素及免疫功能的影响  

Curative Effect of Bushen Tiaojing Cream in Treatment of Premature Ovarian Failure(Kidney Deficiency) and Its Influnce of Sex Hormone and Immune Function

作　　者：赵小迎 谢一红 郑胡忠 陈浩波 ZHAO Xiaoying;XIE Yihong;ZHENG Huzhong;CHEN Haobo(Department of Obstetrics and Gynecology,Wenzhou Traditional Chinese and Western Medicine Hospital,Wenzhou 325000,Zhejiang,China)

机构地区：[1]温州市中西医结合医院妇产科,浙江温州325000

出　　处：《中华中医药学刊》2019年第1期192-196,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划项目(2015ZB110)

摘　　要：目的:分析补肾调经膏方治疗肾虚型卵巢早衰的疗效及对患者性激素及免疫功能的影响,探讨其临床适用性。方法:78例18～35岁肾虚型卵巢早衰患者,采用随机数字表法分为对观察组39例和对照组39例,对照组患者给予人工周期疗法,戊酸雌二醇片1 mg,每天1次,连服21 d;于服雌激素后第12天加服黄体酮胶囊200 mg,每日2次,连续10 d。观察组患者采用补肾调经膏方治疗,每次20 mL口服,每天2次。1个月为1个疗程,共治疗3个疗程。疗程结束后随访10个月,比较两组患者治疗前后月经改善、妊娠情况、中医症状积分、性激素(LH, E2,FSH及P)、免疫功能指标(lgA、lgG、CD4及CD8)的改善情况。结果:观察组患者治疗后月经改善率为94.87%(37/39),对照组患者为79.49%(31/39),两组患者月经改善率比较,差异有统计学意义(χ~2=4.129 4,P=0.042 1)。观察组患者的月经改善时间明显短于对照组,差异也有统计学意义(t=2.329 4,P=0.022 9)。观察组患者的停经复发率为2.56%(1/39),对照组患者为15.38%(6/39),两组患者停经复发率比较,差异也有统计学意义(χ~2=3.923 5,P=0.047 6)。两组患者治疗前月经异常,腰膝酸软,潮热汗出,畏寒肢冷,性欲减退,阴道干涩积分比较,差异均无明显统计学意义(P>0.05),治疗后上述积分均显著降低,差异有统计学意义(P<0.05),且观察组患者治疗后月经异常,腰膝酸软,潮热汗出,畏寒肢冷,性欲减退,阴道干涩积分均显著低于对照组患者,差异有统计学意义(P<0.05)。两组患者治疗前LH, E_2,FSH及P水平均无明显统计学差异(P>0.05),治疗后E_2及P明显升高,LH和FSH回落,差异有统计学意义(P<0.05),且观察组患者各项激素水平均优于对照组患者,差异有统计学意义(P<0.05)。两组患者治疗后lgA、lgG、CD4及CD8免疫指标与治疗前相比,均显著升高,差异均有统计学意义(P<0.05),且观察组患者的lgA、lgG、CD4及CD8均明显高于对照组,差异有统�Objective:To analyze the clinical effect of Bushen Tiaojing Cream in the treatment of premature ovarian failure(kideny deficiency)and its influence of sex hormone and immune function and explore its clinical applicability.Methods:Seventy-eight patients(18~35 years old)of premature ovarian failure(kideny deficiency)were simple randomly by hospitalized number divided into the observation group 39 cases and the control group 39 cases, The control group were treated with the artificial cycle therapy, including Estradiol Valerate Tablets 1 mg, once a day, and even served 21 days.On the twelfth day,patients took estrogen progesterone capsules 200 mg, twice daily for 10 consecutive days, while the observation group patients were treated with Bushen Tiaojing Cream therapy, 20 mL every day, twice a day.One month was 1 course of treatment, a total of 3 courses of treatment.The follow-up period was 10 months after the end of the course.The scores of TCM symptoms, sex hormones(LH, E2, FSH and P), immune function indexes(lgA, lgG, CD4 and CD8)were compared before and after treatment in the two groups.Results: The improvement rate of menstruation in the observation group after treatment was 94.87%(37/39), while that in the control group was 79.49%(31/39).The difference was statistically significant(χ^2=4.129 4,P=0.042 1).The menstrual improvement time of the patients in the observation group was significantly shorter than that of the control group and the difference was statistically significant(t=2.329 4,P=0.022 9).The rate of menopause recurrence in the observation group was 2.56%(1/39)and the control group was 15.38%(6/39)and the difference was statistically significant(χ^2=3.923 5,P=0.047 6).The differences of symptom score(abnormal menstruation, lumbar and wasit pain, hot flashes sweating, aversion to cold, loss of libido, vaginal dryness)of two groups were statistically significant after treatment(P>0.05).The scores were remarkably reduced and the difference was statistically significant(P<0.05), and those of the obser

关 键 词：补肾调经膏方 肾虚型 卵巢早衰 性激素 免疫功能 

分 类 号：R588.6[医药卫生—内分泌]