161例门诊抗生素输液药物不良反应原因分析及干预措施  

Cause Analysis and Intervention Measures of Adverse Drug Reactions of Antibiotic Infusion in 161 Outpatients

作　　者：程璐 Cheng Lu(The First People's Hospital of Chuzhou,Chuzhou 239000,China)

机构地区：[1]滁州市第一人民医院药剂科,安徽滁州239000

出　　处：《广东化工》2019年第2期102-103,共2页Guangdong Chemical Industry

摘　　要：目的分析161例门诊输液患者抗生素药物不良反应的原因,提出干预措施,为门诊输液患者提供安全用药依据。方法选取我院2017年1月～2017年4月门诊接受抗生素输液治疗的患者719例,其中161人次(8.3%)发生抗生素不良反应,收集这161例抗生素药物不良反应患者临床资料,分析抗生素药物临床不良反应的原因,并针对性的干预措施。结果 161例门诊抗生素输液药物不良反应患者中,患者明确自己过去过敏史的36例(22.36%),未有过敏史的68例(42.23%),未知过敏史的57例(35.40%);随着年龄的增长,抗生素产生的不良反应发生率逐渐增加,其主要集中在>60岁的患者;161例患者中使用β-内酰胺类78例(36%),喹诺酮类52例(32.3%),林可霉素类30例(18.6%),大环内脂类21例(13.0%);主要的不良反应为皮肤及其附件不良反应100例(62.12%)、心血管系统22例(13.66%)、消化系统不良反应13例(8.08%);106例患者均对症治疗,未出现严重不良反应事件。结论门诊输液治疗中抗生素不良反应影响因素主要有年龄、过敏史、抗生素类型,采取合理的用药方案及管理,继而提高用药安全性及合理性,减少不良反应的发生率。Objective: Objective to analyze the causes of adverse reactions of antibiotics in 161 outpatients with infusion, and put forward intervention measures to provide safe medication basis for outpatients with transfusion. Methods: 719 Cases of patients in our hospital from January 2017-2017 April outpatient antibiotic infusion therapy, of which 161 passengers(8.3 %) adverse reactions of antibiotics, this collection of 161 cases of antibiotic drug adverse reactions in patients with clinical data, analysis of the causes of clinical adverse reactions to antibiotics, and targeted interventions. Results:161 cases of outpatient infusion of antibiotics adverse drug reactions in patients, patients with clear past history of allergy in 36 cases(22.36 %), 68 patients with no history of allergies(42.23 %), 57 cases of unknown allergy history(35.40 %);with the increase of age, the incidence of adverse reactions of antibiotics increased, the main concentrated in the > 60 years old patients;beta lactam 78 cases in 161 patients(36 %), 52 cases of quinolones(32.3 %), lincomycins(18.6 %), 30 cases of macrolides in 21 cases(13 %);the main adverse reactions of 100 cases of adverse reactions of skin and its accessories(62.12 %), 22 cases of cardiovascular system(13.66 %), 13 cases of adverse reactions of digestive system(8.08 %);106 patients were symptomatic treatment, no serious adverse events. Conclusion: The main influencing factors of antibiotic adverse reactions in outpatient infusion therapy are age, history of allergy, type of antibiotics, rational drug use plan and management, and then improve the safety and rationality of drug use, reduce the incidence of adverse reactions.

关 键 词：门诊 抗生素 不良反应 管理 

分 类 号：TQ[化学工程]