核素心血池显像评价肺动脉高压患者右心室不同步性的研究  

Assessment of right ventricular dyssynchrony in patients with pulmonary hypertension using equilibrium radionuclide angiography

作　　者：陈雨[1] 谷阳 林振宇[1] 徐海燕[1] 严山[1] 马树人[1] 张喜文[1] CHEN Yu;GU Yang;LIN Zhen-yu;XU Hai-yan;YAN Shan;MA Shu-ren;ZHANG Xi-wen(Department of Cardiology,Huai'an First People's Hospital,Nanjing Medical University,Huai'an,Jiangsu 223300,China)

机构地区：[1]南京医科大学附属淮安市第一人民医院心内科,江苏淮安223300

出　　处：《中国临床医学影像杂志》2019年第1期4-7,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:探讨核素心血池显像评价肺动脉高压患者右心室不同步性的价值。方法:入选35例肺动脉高压(PH)患者和20例健康人为对照组。使用ERNA的相位分析软件,计算不同步参数右心室相角程(RVmPA),右心室峰相位标准差(RVPSD)和右心室射血分数(RVEF)。同时测量6分钟步行距离(6-MWD)和N末端B型利钠肽原(NT-proBNP)来评价PH患者的右心室功能。结果:PH组患者的RVEF,RVmPA和RVPSD分别为(36.57±7.43%,(403.91±81.78)ms和(54.46±15.05)ms)。与对照组(48.55±7.22,(251.61±68.44)ms和(36.09±11.55)ms)相比,RVEF明显减低(P<0.001),右心室不同步参数RVmPA和RVPSD也明显增大(P <0.001)。不同步参数RVmPA和RVPSD与RVEF,6-MWD和NT-proBNP有显著相关性(RVmPA:R=0.725,0.645,0.633,P<0.001;RVPSD:R=0.804,0.733,0.725,P<0.001)。结论:ERNA的相位分析技术可以评价PH患者的右心室不同步性。ERNA的右心室不同步参数与右心功能有显著相关性。Objective:The purpose of this study was to evaluate the right ventricular (RV)dyssynchrony in pulmonary hypertension (PH)patients using equilibrium radionuclide angiography (ERNA).Methods:Thirty-five PH patients and twenty healthy controls were included.ERNA was performed to calculate both RV ejection fraction (RVEF)and dyssynchrony parameters including RV phase shift(RVmPA)and RV phase standard deviation(RVPSD).The 6-minute walking distance(6-MWD)and N-terminal pronatriuretic peptide (NT-proBNP)were also detected to evaluate RV function of PH patients.Results:The mean RVEF,RVmPA and RVPSD of the PH group were 36.57±7.43%,(403.91±81.78)ms,and (54.46±15.05)ms,respectively.Compared with the control group,RVEF was significantly decreased (P<0.001),while RVmPA and RVPSD were significantly increased (P<0.001).RVmPA and RVPSD were significantly correlated with RVEF,6-MWD and NT-proBNP (RVmPA:r=0.725, 0.645,0.633,P<0.001;RVPSD:r=0.804,0.733,0.725,P<0.001).Conclusion:ERNA is feasible to evaluate RV mechanical dyssynchrony in PH patients.RV dyssynchrony parameters measured by phase analysis of ERNA were significantly correlated with RV function.

关 键 词：高血压 肺性 心室功能 右 门控血池显像 

分 类 号：R541.3[医药卫生—心血管疾病] R817.4[医药卫生—内科学]