血管内皮细胞衰老与心血管疾病的相关性  

Relationship between vascular endothelial cell senescence and cardiovascular disease

作　　者：卿即娜 陈红阳 尹琳洁 尹凯 QING Jina;CHEN Hongyang;YIN Linjie;YIN Kai(Research Lab of Translational Medicine,Hengyang Medical School,University of South China,Hengyang,Hunan 421001,China;Department of Plastic and Cosmetic Laser Surgery,Hunan Provincial People's Hospital,Changsha, Hunan 410005,China)

机构地区：[1]南华大学衡阳医学院转化医学研究室,湖南省衡阳市421001 [2]湖南师范大学第一附属医院湖南省人民医院整形激光美容外科,湖南省长沙市410005

出　　处：《中国动脉硬化杂志》2019年第2期161-168,共8页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金(81100213;81470569);湖南省自然科学基金(2018JJ2341);南华大学博士启动基(2015XQD49);南华大学留学归国人员启动基金(2015XQD55)

摘　　要：血管内皮细胞(VEC)是覆盖于血管内膜表面的单层扁平鳞状上皮细胞,其构成血管壁的生物屏障,不仅属于一种保护性屏障,还能够产生一些自体分泌物用于调节体内平衡和血管紧张度。VEC衰老可导致血管功能受损,是心血管系统(CVS)主要的危险因素,并与心血管疾病(CVD)有着密切的关系。然而,VEC衰老的机制以及VEC衰老对血管功能的影响尚不完全清楚。本综述总结了VEC衰老的特征及其相关分子机制,并对年龄相关CVD进行了阐述。The vascular endothelial cell( VEC) is a single layer of flat squamous epithelium covering the intima of the blood vessel. It constitutes a biological barrier to the blood vessel wall. It is not only a protective barrier but also produces some autocrine secretion. The substance is used to regulate homeostasis and vascular tone and has a variety of biological functions. VECsenescence can lead to vascular dysfunction,which is a major risk factor for cardiovascular system( CVS) and has a close relationship with cardiovascular disease( CVD). However,themechanism of VEC senescence and the effects of VEC senescence on vascular function are not fully understood. This review summarizes the characteristics of VEC senescence and its related molecular mechanisms,and describes age-related CVD.

关 键 词：血管内皮细胞 衰老 心血管疾病 

分 类 号：R5[医药卫生—内科学]