氧化三甲胺致动脉粥样硬化作用及其防治的研究进展  

Research progress on atherosclerosis induced by trimethylamine oxide and its prevention and treatment

作　　者：王焕辉 王蓓[2] 覃咏梅 林玲[2] WANG Huanhui;WANG Bei;QIN Yongmei;LIN Ling(Department of General Practice,the Third People's Hospital of Hainan Province,Sanya, Hainan 572000,China;Department of Cardiology,the Third People's Hospital of Hainan Province,Sanya, Hainan 572000,China;Graduate School of Guangzhou Medical University,Guangzhou,Guangdong 510000,China)

机构地区：[1]海南省第三人民医院全科医学科,海南省三亚市572000 [2]海南省第三人民医院心内科,海南省三亚市572000 [3]广州医科大学研究生学院,广东省广州市510000

出　　处：《中国动脉硬化杂志》2019年第2期175-179,共5页Chinese Journal of Arteriosclerosis

摘　　要：氧化三甲胺(TMAO)是由胆碱等物质依赖于肠道菌群代谢生成的产物。近年来,国内外研究发现TMAO在动脉粥样硬化(As)发生、发展过程中起重要作用,TMAO通过介导血管内皮细胞炎症信号和基因的表达、增加血栓形成风险、上调清道夫受体和促进泡沫细胞形成、影响胆固醇转运途径及其代谢通路等方式促进As。本文对近年来相关文献报道进行总结,发现通过控制饮食、调节肠道菌群、抑制三甲胺前体代谢、抑制黄素单加氧酶活性等方式,可以降低血液循环的TMAO水平,阻止As进展。Trimethylamine oxide( TMAO) is a product which is formed by the metabolism of choline and other substances depending on the intestinal microflora. In recent years,studies at home and abroad have found that TMAO plays an important role in the occurrence and development of atherosclerosis( As). TMAO promotes As by mediating inflammatory signals and gene expression in vascular endothelial cells,increasing thrombosis risk,increasing scavenger receptor and promoting foam cell formation,influencing cholesterol transport pathways and metabolic pathways. This paper summarizes the related literatures in recent years,and finds that by controlling diet,regulating intestinal flora,inhibiting trimethylamine precursor metabolism,inhibiting flavin monooxygenase activity,TMAO level in blood circulation can be reduced and As progress can be prevented.

关 键 词：氧化三甲胺 动脉粥样硬化 肠道菌群 三甲胺裂解酶 黄素单加氧酶 

分 类 号：R54[医药卫生—心血管疾病]