慢性肾脏病患者血管钙化相关生物学标志物  

Biomarkers of vascular calcification in patients with chronic kidney disease

作　　者：谢海英[1] 李青华[1] 何剑零[1] 包国祥[2] 黄迪华[3] XIE Haiying;LI Qinghua;HE Jianling;BAO Guoxiang;HUANG Dihua(Department of Nephrology,Shaoxing People's Hospital,Shaoxing ,Zhejiang 312000,China;Department of Clinical Laboratory,Shaoxing People's Hospital,Shaoxing ,Zhejiang 312000,China;Department of Endocrinology,Shaoxing People's Hospital,Shaoxing ,Zhejiang 312000,China)

机构地区：[1]绍兴市人民医院肾内科,浙江省绍兴市312000 [2]绍兴市人民医院检验科,浙江省绍兴市312000 [3]绍兴市人民医院内分泌科,浙江省绍兴市312000

出　　处：《中国动脉硬化杂志》2019年第2期180-184,共5页Chinese Journal of Arteriosclerosis

基　　金：绍兴市公益性技术应用研究计划项目(2015B70050;2017B70028)

摘　　要：血管钙化是慢性肾脏病患者心血管死亡的主要原因,是患者死亡率强有力的预测因子。随着慢性肾脏病的进展,血管钙化发生率不断增加。因此需要找到预测血管钙化的生物标志物,用来预测未来心血管事件发生率和致死率,进行相应干预,改善患者预后。现已有不少关于慢性肾脏病患者血管钙化生物标志物的相关研究,文章就这些生物标志物进行了简要的综述。Vascular calcification( VC) is associated with an increased cardiovascular morbimortality in chronic kidney disease( CKD). The prevalence of VC increases steadily through the stages of chronic kidney disease. Well-designed clinical trials are urgently needed to test the potential value of these biomarkers as a guide for interventions targeting VC now. This review gives a brief overview of the circulating biomarkers of vascular calcification in CKD patients.

关 键 词：生物标志物 慢性肾脏病 血管钙化 

分 类 号：R5[医药卫生—内科学]