表观扩散系数值评估克罗恩病的活动性  

Assessment of Crohn’s disease activity with apparent diffusion coefficient value

作　　者：廖亮 曾艳[1] 王利娜[1] 徐云霞[1] 钱银锋[1] LIAO Liang;ZENG Yan;WANG Lina;XU Yunxia;QIAN Yinfeng(Department of Radiology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学第一附属医院放射科,安徽合肥230022

出　　处：《实用放射学杂志》2019年第1期65-67,72,共4页Journal of Practical Radiology

摘　　要：目的 探讨ADC值评估克罗恩病(CD)活动性的价值。 方法 回顾性分析35例经组织病理学证实的CD患者的磁共振小肠成像(MRE)及DWI资料,测量病变肠壁ADC值,以CD活动指数(CDAI)作为疾病活动性参考标准,分析ADC值与CD活动性的关系。 结果 35例病例中,CD缓解期(CDAI<150)14例,活动期(CDAI≥150)21例,缓解期和活动期病变肠壁ADC值分别为(1.51±0.27)×10^-3 mm^2/s、(1.23±0.16)×10^-3 mm^2/s,两者差异有统计学意义(P<0.05)。病变肠壁ADC值与CDAI评分呈负相关(r=-0.823,P<0.05)。ROC曲线分析显示,ADC值评估CD活动性的AUC较大,为0.912。当ADC阈值为1.32×10^-3 mm^2/s,其诊断CD活动性的敏感性、特异性分别为92.9%、85.7%。 结论 MR定量参数ADC值可较准确地评估CD的活动性。Objective To assess the value of ADC value for evaluating inflammatory activity in patients with Crohn's disease (CD).Methods MR enterography {MRE}and DWI data of 35 patients with histopathologically proven CD were analyzed retrospectively. Taking Crohn's disease activity index (CDAI)as reference of CD activity,ADC values of intestinal wall involved hy CD were measured, and the relationship between ADC values and CD activity was analyzed.Results Of the 35 patients,14 were in paracmasis of CD (CDAI<150)and 21 were active CD (CDAI≥150).The ADC values of catabatic and activity segment were (1.51±0.27)×10^-3mm^2/s and (1.23±0.16)×10^-3mm^2/s respectively,with a significant statistical difference (P<0.05).The ADC value was inversely correlated with CDAI (r =-0.823,P<0.05).The ADC value showed good diagnostic accuracy for CD activity with ROC analysis (AUC=0.912). Taking ADC value of 1.32×10^-3mm^2/s as threshold,the diagnostic sensitivity and specificity was 92.9% and 85.7% respectively. Conclusion Quantitative parameters of MR(ADC value)can be used to assess the inflammatory activity of CD with high accuracy.

关 键 词：扩散加权成像 克罗恩病 活动性 

分 类 号：R445.2[医药卫生—影像医学与核医学] R574[医药卫生—诊断学]