基因易感性与噪声性听力损伤关系的研究进展  

Relationship between susceptible genes and noise-induced hearing loss

作　　者：张靖 杨雅兰 王晔 马良 魏小兰 曾俊 王永伟 ZHANG Jing;YANG Ya -lan;WANG Ye;MA Liang;WEI Xiao -lan;ZENG Jun;WANG Yong -wei(Department of Environmental Health and Occupational Medicine,West China School of Public Health,Sichuan University,Chengdu ,Sichnan 610041,China)

机构地区：[1]四川大学华西公共卫生学院(华西第四医院),四川成都610041 [2]四川大学华西公共卫生学院流行病与卫生统计学系,四川成都610041 [3]成都飞机工业(集团)有限责任公司,四川成都610041 [4]四川大学华西第四医院职业危害评价科四川省职业卫生应急(甲级)重点实验室,四川成都610041

出　　处：《现代预防医学》2019年第3期415-417,451,共4页Modern Preventive Medicine

基　　金：高噪声暴露听力损害个体风险预警模型的研制(项目编号:40101004200X)

摘　　要：噪声性听力损伤是危害接噪工人身体健康的主要职业病。目前有研究表明,造成这一损害的主要原因是环境与遗传因素的共同作用,且遗传因素扮演着重要的角色。大量研究表明氧化应激类基因、单基因耳聋基因、热休克蛋白基因等与噪声性听力损伤的关联较强。现本文对其研究进展进行概述。Noise-induced hearing loss is the main occupational disease,which is harmful to workers who are exposed to noise. Some researches show that the main cause of this damage is the interaction of environmental and genetic factors,and genetic factors play an important role. Numerous studies show that oxidative stress genes,monogenic deafness genes,and heat shock protein genes are related to noise-induced hearing loss. This article is an overview of its research progress.

关 键 词：噪声性听力损伤 易感性 易感基因 

分 类 号：R12[医药卫生—环境卫生学]