宁夏地区回、汉族COPD肺动脉高压患者一氧化氮合酶及内皮素-1的临床相关研究  

Correlation between the levels of plasma ET-1,NOS and the pulmonary artery systolic pressure in patients with stable COPD

作　　者：常湘辉[1] 黄晓波[1] 许旺[1] 陈丽君[1] 邵萍 陈梅[1] CHANG Xianghui;HANG Xiaobo;XU Wang;CHENG Lijun;SHAO Ping;CHEN Mei(The First People's Hospital of Yinchuan ,Yinchuan 750001,China)

机构地区：[1]宁夏银川市第一人民医院呼吸内科,宁夏银川750001

出　　处：《宁夏医学杂志》2018年第12期1120-1122,共3页Ningxia Medical Journal

基　　金：宁夏卫生计生委重点科研项目(2015-NW-077)

摘　　要：目的探讨宁夏地区回、汉族慢性阻塞性肺疾病(COPD)稳定期患者血浆内皮素-l(ET-1)、一氧化氮合酶(NOS)水平与肺动脉高压之间的关系。方法检测COPD合并肺动脉高压患者及正常对照组人群的血浆ET-1、NOS水平,比较2组研究对象的血浆ET-1、NOS水平,并将回、汉族COPD肺动脉高压患者血浆ET-1、NOS水平进行对比。结果 COPD肺动脉高压患者ET-I水平较正常对照组明显升高(P <0. 05),血浆NOS水平较正常对照组明显降低(P <0. 05);回、汉族COPD肺动脉高压患者血浆ET-1、NOS水平差异无统计学意义(P>0. 05)。结论 ET-1与NO的失衡,可引起患者血流动力学及病理结构的变化。可能是COPD形成肺动脉高压的机制之一。Objective To investigate the relationship among the levels of plasma endothelin-1( ET-1),nitric oxide synthase( NOS) and the pulmonary artery systolic pressure in the patients with the stable period of chronic obstructive pulmonary disease( COPD). Methods The patients with the stable period of COPD were collected and divided into Hui group and Han group. Normal subjects were chosen to be the controls. The levels of plasma ET-1 and NOS were detected and compared among the three groups.Results Compared with the control group,the levels of plasma ET-1 in pulmonary hypertension group were increased significantly( P < 0. 05). The levels of plasma NOS in pulmonary hypertension group were decreased significantly( P < 0. 05). The levels of plasma NOS and ET-1 was no difference between hui and han group. Conclusion Unbalance of ET-1 and NOS may be one of the mechanisms that cause pulmonary hypertension.

关 键 词：慢性阻塞性肺病 肺动脉高压 一氧化氮合酶 内皮素-1 

分 类 号：R544.3[医药卫生—心血管疾病]