2型糖尿病肾病患者血清晚期氧化蛋白产物与动脉粥样硬化的关系  

Relationship between serum advanced oxidation protein products and atherosclerosis in patients with type 2 diabetic nephropathy

作　　者：荣光 卓华钦 叶庆邦 宁海欢 朱咏瑶 杨银广 林志坚 蔡茵瑜 RONG Guang;ZHUO Hua-qin;YE Qing-bang;NING Hai-huan;ZHU Yong-yao;YANG Yin-guang;LIN Zhi-jian;CAI Yin-yu(Department of Nephrology ,Third People's Hospital of Dongguan,Dongguan 523326,Guangdong,CHINA;Department of Endocrinology ,Third People's Hospital of Dongguan,Dongguan 523326,Guangdong,CHINA;B-ultrasound Room,Department of Functional Examination ,Third People's Hospital of Dongguan,Dongguan 523326,Guangdong,CHINA;Department of Clinical Laboratory,Third People's Hospital of Dongguan,Dongguan 523326,Guangdong,CHINA;Department of Health Management, Third People's Hospital of Dongguan,Dongguan 523326,Guangdong,CHINA)

机构地区：[1]东莞市第三人民医院肾内科,广东东莞523326 [2]东莞市第三人民医院内分泌科,广东东莞523326 [3]东莞市第三人民医院功能检查科B超室,广东东莞523326 [4]东莞市第三人民医院检验科,广东东莞523326 [5]东莞市第三人民医院健康管理科,广东东莞523326

出　　处：《海南医学》2019年第2期166-168,共3页Hainan Medical Journal

基　　金：2017年广东省东莞市社会科技发展项目(编号:201750715024134)

摘　　要：目的探讨2型糖尿病肾病患者血清晚期氧化蛋白产物(AOPP)与动脉粥样硬化的关系。方法检测2017年7月至2018年6月在东莞市第三人民医院住院治疗的50例2型糖尿病肾病(非透析)患者、30例单纯2型糖尿病患者(无并发症)及30例健康体检者血清AOPP的含量,彩色多普勒超声测量颈动脉内中膜厚度(IMT)。通过多变量偏相关分析研究AOPP与动脉粥样硬化的相关性。结果 2型糖尿病肾病组及单纯2型糖尿病组患者血清AOPP[(76.83±4.96)μmol/L、(60.28±3.92)μmol/L]较健康对照组[(26.91±2.18)μmol/L]显著升高,差异均有统计学意义(P<0.05);2型糖尿病肾病患者中IMT正常组患者的血清AOPP为(35.28±3.92)μmol/L,明显低于IMT增厚组的(61.83±4.96)μmol/L,差异有统计学意义(P<0.05);且多变量相关分析表明,血清AOPP与颈动脉IMT值呈显著正相关性(r=0.335,P<0.01)。结论 2型糖尿病肾病患者血清AOPP与颈动脉IMT呈正相关,可能促进2型糖尿病肾病患者动脉粥样硬化的发生发展。Objective To explore the relationship between advanced oxidation protein products(AOPP) and atherosclerosis(AS) in patients with type 2 diabetic nephropathy. Methods A total of 50 patients with type 2 diabetic nephropathy(non-dialysis) hospitalized in the Third People’s Hospital of Dongguan from July 2017 to June 2018, 30 patients with type 2 diabetes mellitus(without complications), and 30 healthy subjects were examined for AOPP content.The mean intima-media thickness(IMT) of carotid artery was measured by ultrasonography. Correlation between AOPP and atherosclerosis was studied by multivariate partial correlation analysis. Results Serum AOPP in the type 2 diabetic nephropathy group and the type 2 diabetes mellitus group were(76.83±4.96) μmol/L,(60.28±3.92) μmol/L, significantly higher than(26.91±2.18) μmol/L in the healthy control group(P<0.05). Serum AOPP in type 2 diabetic nephropathy patients with normal IMT was(35.28±3.92) μmol/L, which was significantly lower than(61.83±4.96) μmol/L in the patients with IMT thickening(P<0.05). Multivariate correlation analysis showed a significant positive correlation between serum AOPP and carotid IMT(r=0.335, P<0.01). Conclusion In patients with type 2 diabetic nephropathy, AOPP was positively correlated with carotid artery IMT and may involved in the occurrence and development of atherosclerosis.

关 键 词：2型糖尿病肾病 2型糖尿病 氧化蛋白产物 动脉粥样硬化 

分 类 号：R587.2[医药卫生—内分泌]