超声造影时间-强度曲线分析冠心病患者颈动脉斑块内新生血管与高同型半胱氨酸的关系  

Relationship between carotid atherosclerotic plaques neovascularization and high homocysteine in patients with coronary artery disease analyzed by time-intensity curve of contrast-enhanced ultrasound

作　　者：彭红艳[1] 李小晶[1] 贾海珍[2] 余松远[1] 李蕾[1] 张玲[1] PENG Hongyan;LI Xiaojing;JIA Haizhen;YU Songyuan;LI Lei;ZHANG Ling(Department of Ultrasonic Medicine Tianyou Hospital Affiliated to Wuhan University of Science and TechnoLogy,Wuhan,Hubei 430064,China;Department of Cardiovascular,Tianyou Hospital Affiliated to Wuhan University of Science and TechnoLogy,Wuhan,Hubei 430064,China)

机构地区：[1]武汉科技大学附属天佑医院超声医学科,武汉430064 [2]武汉科技大学附属天佑医院心内科,武汉430064

出　　处：《重庆医学》2019年第1期64-66,共3页Chongqing medicine

基　　金：武汉科技大学青年科技骨干培育计划项目(2016xz024)

摘　　要：目的通过超声造影时间-强度曲线量化分析冠状动脉粥样硬化性心脏病(CAD)患者颈动脉斑块内新生血管,探讨斑块稳定性与高同型半胱氨酸(Hcy)的关系。方法选取该院就诊的87例CAD患者分为两组:CAD合并Hcy组(合并组,45例),CAD组(42例),所有患者均行常规颈动脉超声检查,对其中75例有颈动脉斑块患者行超声造影检查,采用SonoLiver声学定量软件测量斑块达峰时间(TTP)、最大峰值强度比(IMAX%)、曲线下面积(AUC),并进行组间比较,量化分析CAD患者颈动脉斑块稳定性与Hcy的相关关系。结果合并组斑块发生率及软斑个数较CAD组高,差异有统计学意义(P<0.05);两组间斑块TTP、IMAX%、AUC进行比较,差异均有统计学意义(P<0.05)。结论超声造影时间-强度曲线可对CAD患者颈动脉斑块内新生血管分布及斑块稳定性进行量化评价,斑块不稳定性和Hcy是CAD发生、发展的高危因素。Objective To explore the correlation between plaque stability and high homocysteine(Hcy)in patients with coronary artery disease(CAD),with quantitative analysis of carotid atherosclerotic plaques neovascularization by time-intensity curve of contrast-enhanced ultrasound.Methods 87 patients with CAD in our hospital were divided into two groups:the CAD combined with Hcy group(45 patients),and the CAD group(42 patients).All patients were observed by carotid ultrasound.Among them,75 patients with carotid atherosclerosis were observed through real-time contrast-enhanced ultrasound.Time to peak(TTP),the ratio of maximum intensity(IMAX%)and area under the curve(AUC)of carotid plaques were calculated with SonoLiver analysis software.The relationship between plaque stability and Hcy in patients with CAD was analyzed accordingly.Results The plaque incidence and the number of soft plaque in the CAD combined with Hcy group were higher than that in the CAD group(P<0.05).TTP,the ratio of IMAX,and AUC were compared respectively and showed statistical differences(P<0.05).Conclusion Time-intensity curve of contrast-enhanced ultrasound can be used to quantitate the carotid atherosclerosis plaque neovascularization and evaluate the plaque stability.The high incidence and instability of plaque in CAD combined with Hcy patients were higher than CAD patients,which sufficiently demonstrates instability of plaque and Hcy as the risk factors in CAD occurrence and development.

关 键 词：超声检查 多普勒 彩色 血管造影术 时间-强度曲线 颈动脉疾病 冠心病 半胱氨酸 

分 类 号：R445.1[医药卫生—影像医学与核医学]