两种酸根离子配体结合位点的识别  

Binding Sites Identification of Two Acid Radical Ion Ligands

作　　者：王珊 张晓瑾 胡秀珍[1] 刘柳 WANG Shan;ZHANG Xiao-jin;HU Xiu-zhen;LIU Liu(College of Sciences,Inner Mongolia University of Technology,Hohhot 010051,China)

机构地区：[1]内蒙古工业大学理学院,内蒙古呼和浩特010051

出　　处：《内蒙古工业大学学报（自然科学版）》2018年第4期246-254,共9页Journal of Inner Mongolia University of Technology：Natural Science Edition

基　　金：内蒙古自然科学基金项目(2016MS0378);国家自然科学基金项目(31260203)

摘　　要：在许多重要的生命活动中,蛋白质功能的执行依赖于蛋白质与配体的相互作用,酸根离子作为一种重要的蛋白质结合配体,其结合位点的识别对于蛋白质功能的研究有着重要意义.本文选取了两种酸根离子配体作为研究对象,提出了基于序列信息的MultilayerPerceptron算法,5-交叉检验下,得到了较好的预测结果.In many important life activities of living beings,how protein functions depends on the interaction between protein and ligand.As an important protein-binding ligand,the identification of the binding site of the acid radical ion ligands plays an important role in the study of the protein function.In the paper,two kinds of acid radical ion ligands were selected as the research object.Multilayer Perceptron algorithm based on sequence information was proposed.Satisfactory prediction results were obtained by the 5-fold cross-validation.

关 键 词：酸根离子配体 MultilayerPerceptron算法 结合位点 位点信息 

分 类 号：Q61[生物学—生物物理学]