抗肿瘤抗生素棘霉素的研究进展  

Research Progress of Antitumor Antibiotic Echinomycin

作　　者：单传坤 李良[1] Shan Chuan-kun;Li Liang(Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences &Peking Union Medical College,Beijing 100050)

机构地区：[1]中国医学科学院北京协和医学院医药生物技术研究所,北京100050

出　　处：《国外医药（抗生素分册）》2019年第1期32-36,共5页World Notes on Antibiotics

摘　　要：醌霉素是一类链霉菌产生的非核糖体肽类的天然产物,结构中的两个喹喔啉环生色团为活性基团,该基团通过插入到DNA碱基对间从而抑制DNA的复制和RNA的合成,这类化合物具有非常广泛的抗菌,抗肿瘤和抗病毒活性。棘霉素是这类化合物之一,是抗肿瘤药物药物研究和开发的重要靶分子。棘霉素的生物合成和抗肿瘤作用机制一直在研究中,综述了近10年来对棘霉素生物合成、抗肿瘤作用机制和应用的最新研究进展,以期待其更广泛的服务于抗肿瘤药物研究。Quinomycins are the natural products of a class of non-ribosomal peptides produced by Streptomyces. The two quinoxaline ring chromophores in the structure are reactive groups that inhibiting DNA replication and RNA synthesis by insertion into DNA base pairs.These compounds have a very broad antibacterial,antitumor and antiviral activity.Echinomycin is one o.f these compounds and it is an important target molecule for antitumor drugs'research and development.The biosynthesis and antitumor mechanism of echinomycin has been studied all the time.This article reviewing the latest research'in the echinomycin's antitumor mechanism,biosynthesis and application of the past 10 years,in anticipation of its wider service to antitumor drugs'research.

关 键 词：棘霉素 生物合成 抗肿瘤 

分 类 号：R961[医药卫生—药理学]