纳洛酮辅助治疗小儿病毒性脑炎的临床疗效分析  

Analysis on the Clinical Curative Effect of Naloxone in the Adjuvant Treatment of Children with Viral Encephalitis

作　　者：韦登峰 黄善周[2] 王凤清 WEI Dengfeng;HUANG Shanzhou;WANG Fengqing(Department of Pediatrics,Xiayi Maternal and Child Hea!thcare Hospital,Maoming 525300,Chino;Department of Pediatrics,Xinyi People's Hospital,Mooming 525300,China;Department of Neonatology,Maoming People's Hospital,Maoming 525000,China)

机构地区：[1]广东省信宜市妇幼保健院小儿内科,广东茂名525300 [2]广东省信宜市人民医院儿科,广东茂名525300 [3]广东省茂名市人民医院新生儿科,广东茂名525000

出　　处：《临床医学工程》2019年第1期59-60,共2页Clinical Medicine & Engineering

摘　　要：目的观察在对症治疗的基础上采用纳洛酮辅助治疗小儿病毒性脑炎的临床疗效。方法选取2015年1月至2018年6月收治的病毒性脑炎患儿84例,随机分为对照组和观察组各42例。对照组采用维持水电解质平衡、退热、降低颅内压、抗病毒等对症治疗,观察组在对照组基础上采用纳洛酮治疗,两组患儿均治疗2个疗程。对比两组患儿的临床疗效、症状体征恢复时间和SF-36评分。结果观察组的临床疗效优于对照组(P <0.05)。观察组的惊厥、脑膜刺激征、头痛呕吐消失时间,以及体温、肌力恢复时间均短于对照组(P <0.05)。治疗前,两组患儿的SF-36评分比较无统计学差异(P>0.05);治疗后,两组的SF-36评分均有所提高,且观察组的SF-36评分高于对照组(P均<0.05)。结论采用纳洛酮辅助治疗小儿病毒性脑炎能够有效提高临床疗效,改善患儿的生活质量,值得临床推广。Objective To observe the clinical curative effect of naloxone in the adjuvant treatment of children with viral encephalitis based on symptomatic treatment.Methods 84 cases of children with viral encephalitis from January 2015 to June 2018 were selected and randomly divided into control group and observation group,with 42 cases in each group.The control group received symptomatic treatment such as balance maintenance of water and electrolyte,defervescence,reduction of intracranial pressure,anti-viral therapy.The observation group was treated with naloxone on the basis of the control group.Both groups were treated for 2 courses.The clinical curative effect,symptom and sign recovery time and SF-36 score were compared between the two groups.Results The clinical curative effect of the observation group was better than that of the control group(P<0.05).The disappearance time of convulsion,meningeal irritation sign and headache vomiting,and the recovery time of body temperature and muscle strength of the observation group were shorter than those of the control group(P<0.05).Before treatment,no statistical difference was found in the SF-36 score between the two groups(P>0.05).After treatment,the SF-36 scores of both groups increased,and the SF-36 score of the observation group was higher than that of the control group(all P<0.05).Conclusions Naloxone in the adjuvant treatment of children with viral encephalitis can effectively improve the clinical curative effect,and improve the quality of life of children,which is worthy of clinical promotion.

关 键 词：儿童 病毒性脑炎 纳洛酮 生活质量 

分 类 号：R725.1[医药卫生—儿科]