淫羊藿次苷Ⅱ的药理作用研究进展  

Research progress in pharmacological effect of icariside Ⅱ

作　　者：鞠静 谭人千 潘宇政[1] JU Jing;TAN Ren-qian;PAN Yu-zheng(The First Affiliated Hospital of Guangxi Medical University,Nanning 530021)

机构地区：[1]广西医科大学第一附属医院,南宁530021

出　　处：《中南药学》2019年第1期65-69,共5页Central South Pharmacy

基　　金：国家自然科学基金项目(No.81460687)

摘　　要：淫羊藿是我国传统的补益类中药,具有补肾阳、强筋骨和祛风湿等作用。淫羊藿苷是其主要的黄酮苷类化合物之一,淫羊藿次苷Ⅱ(icarisideⅡ,ICS-Ⅱ)是淫羊藿苷的主要代谢产物之一,具有多种药理作用。本文综述了近年来淫羊藿次苷Ⅱ的剂型研究、生物利用度及其抗肿瘤、抑制骨质疏松和神经保护等药理作用的研究进展,为淫羊藿次苷Ⅱ的进一步开发和利用提供参考。Epimedium,a traditional Chinese tonic herb,may improve the deficiency of kidney,strengthen the bones and muscles,and expel wind-damp.Icariin is one of the main flavonoids;Icariside Ⅱ(ICS-Ⅱ)is one of the main metabolites of icariin,with various pharmacological effects.This study briefly reviewed the recent advances in the bioavailability,anti-tumor,inhibition of osteoporosis and neuroprotective effects of ICS-Ⅱ,and provided a reference for further exploitation and application of ICS-Ⅱ.

关 键 词：淫羊藿次苷Ⅱ 生物利用度 抗肿瘤 抗骨质疏松 神经保护 研究进展 

分 类 号：R285.5[医药卫生—中药学]