产气肠杆菌耐药机制的研究新进展  

Research progress in drug resistance mechanism of Enterobacter aerogenes

作　　者：刘阳 秦旭平[2] 刘英[1] 姚志红[1] 易竹荣 郭利民[1] 任志强[1] LIU Yang;QIN Xu-ping;LIU Ying;YAO Zhi-hong;YI Zhu-rong;GUO Li-min;REN Zhi-qiang(Department of Pharmacy,Yiyang Central Hospital,Yiyang Hunan 413000;Laboratory of Vascular Biology,Institute of Pharmacy and Pharmacology,University of South China,Hengyang Hunan 421001;Department of Vasculocardiology,Yiyang Central Hospital,Yiyang Hunan 413000)

机构地区：[1]益阳市中心医院药剂科,湖南益阳413000 [2]南华大学药物药理研究所血管生物学实验室,湖南衡阳421001 [3]益阳市中心医院心内科,湖南益阳413000

出　　处：《中南药学》2019年第1期70-74,共5页Central South Pharmacy

基　　金：湖南省卫计委科研基金课题(No.2015-295)

摘　　要：产气肠杆菌是一种兼性厌氧的革兰阴性杆菌,近年来其耐药现象在临床上较为突出,其引发的感染已成为全世界的主要关注问题。介导产气肠杆菌耐药的机制主要有主动外排系统、膜孔蛋白改变、产β-内酰胺酶及生物膜形成等。了解产气肠杆菌耐药机制将为临床抗菌药物合理使用提供理论依据。本文就其耐药机制的研究进展进行综述。Enterobacter aerogene is a facultative anaerobic Gram-negative bacilli. In recent years, its drug resistant phenomenon is clinically prominent, and the infection caused has become a main concern worldwide. The mechanism of drug resistance of Enterobacter aerogenes included active efflux system, change of membrane pore protein, and production of β-lactamase and biofilm formation. Understanding the resistance mechanism of Enterobacter aerogenes helps provide theoretical basis for the rational use of antibiotics. This paper summarized the research progress in its resistance mechanism.

关 键 词：产气肠杆菌 耐药机制 研究进展 

分 类 号：R466.5[医药卫生—临床医学]