白芨多糖在药剂领域的应用  

Pharmaceutical application of Bletilla striata(Thunb.) Reichb.f. polysaccharide

作　　者：陈正坤 王嘉兴 林平 林锋 CHEN Zheng-kun;WANG Jia-xing;LIN Ping;LIN Feng(Department of Organic Chemistry,College of Pharmacy,Harbin Medical University,Harbin 150081;Department of Biochemistry and Molecular Biology,College of Basic.Medical Science,Harbin Medical University,Harbin 150081)

机构地区：[1]哈尔滨医科大学药学院有机化学教研室,哈尔滨150081 [2]哈尔滨医科大学基础医学院生物化学与分子生物学教研室,哈尔滨150081

出　　处：《中南药学》2019年第1期74-77,共4页Central South Pharmacy

基　　金：国家自然科学基金资助项目(No.81502199);黑龙江省教育厅课题(No.12531300)

摘　　要：寻找理想的新型药物递送载体材料一直是药学领域的研究热点。白芨多糖是一种新型的天然高分子材料,作为制剂材料在药剂领域有着广泛的应用前景。本文对近十余年来国内外以白芨多糖及白芨多糖衍生物为制剂材料、药物载体,尤其是作为血管栓塞材料、基因载体和聚合物胶束材料在抗肿瘤药物递送领域的文章进行综述,以期为白芨多糖相关领域的科研工作者提供参考。Finding the ideal new drug delivery vehicle material has always been a hot topic in the pharmaceutical research. Bletilla striata(Thunb.) Reichb. f. polysaccharide, as a new type of natural polymer, and a preparation material, has a wide range of applications. This review summarized recent literature on the use of Bletilla striata(Thunb.) Reichb. f. polysaccharide and its derivatives as drug carriers and preparation materials, especially as a vascular embolization material, gene carrier, polymer micelle material in the anti-tumor drug delivery, and provided literature reference for pharmaceutical researchers.

关 键 词：白芨多糖 生物黏附剂 血管栓塞剂 阳离子化多糖基因载体 聚合物胶束 

分 类 号：R965[医药卫生—药理学]