米托蒽醌在脉冲沉积金修饰电极上的电化学行为  

Electrochemical behavior of mitoxantrone at GCE modified with gold by pulse deposition

作　　者：贾瑞虹[1] 白慧云[1] 郭珈玲 孟奎奎 贺艳斌[1] JIA Rui-hong;BAI Hui-yun;GUO Jia-ling;MENG Kui-kui;HE Yan-bin(Department of Pharmacy,Changzhi Medical College,Changzhi 046000)

机构地区：[1]长治医学院药学系,长治046000

出　　处：《分析试验室》2019年第1期52-55,共4页Chinese Journal of Analysis Laboratory

基　　金：山西省自然科学基金面上青年基金项目(201701D221046);山西省大学生创新创业训练项目(2016308);长治医学院科技启动基金项目(普及项目QDZ201647)资助

摘　　要：采用脉冲电沉积法在裸玻碳电极上制得了金修饰电极,并用差分脉冲伏安法(DPV)研究了米托蒽醌(MTX)在该修饰电极上的电化学行为。当介质为0. 1 mol/L HCl时,伏安曲线出现了2个明显的氧化峰P1(峰电位为0. 64 V)和P2(峰电位为0. 72 V)。在最优实验条件下,M TX的峰电流(0. 72 V)在1. 0～50μmol/L的浓度范围内呈良好的线性关系,检出限为0. 21μmol/L。方法可用于米托蒽醌药物含量的测定。Gold modified bare glassy carbon electrode was constructed by pulse deposition,and the electrochemical behavior of mitoxantrone(MTX)at this modified electrode was also investigated by differential pulse voltammetry(DPV).In a 0.1 mol/L HCl solution,a couple of sensitive oxidation peaks of mitoxantrone P1(potential 0.64 V)and P2(potential 0.72 V)were obtained.Under the optimized experimental conditions,the P2 peak current was linearly correlated with MTX concentration from 1.0 to 50 μmol/L and a detection limit of 0.21 μmol/L was obtained.This method can be successfully used in the determination of MTX with satisfactory results.

关 键 词：米托蒽醌 脉冲沉积 金修饰电极 差分脉冲伏安法 

分 类 号：R917[医药卫生—药物分析学]