2-乙基-3,7-二甲基-6-[4-(-氟甲氧基)苯氧基]喹啉的合成  

Synthesis of 2-Ethyl-3-methyl-6-[4-(trifluoromethoxy)phenoxy]quinoline

作　　者：孙鑫建 李晓涵 鲍仪礼 王庆珍 丛文霞 李纪兴 SUN Xin-jian;LI Xiao-han;BAO Yi-li;WANG Qing-zhen;CONG Wen-xia;LI Ji-xing(Linyi University a.School of Chemistry & Chemical Engineering;b.School of Physics & Electronic Engineering,Linyi 276000,Shandong,China)

机构地区：[1]临沂大学化学化工学院,山东临沂276000 [2]临沂大学物理与电子工程学院,山东临沂276000

出　　处：《农药》2019年第1期21-22,39,共3页Agrochemicals

基　　金：临沂大学大学生创新创业训练计划项目(201810452143)资助;临沂大学博士启动基金(40618090)资助

摘　　要：[目的]对flometoquin的关键中间体类似物进行合成。[方法]以取代苯胺和丙醇作为起始原料,经钯催化体系反应高效得到目标产物2-乙基-3,7-二甲基-6-[4-(-氟甲氧基)苯氧基]喹啉。[结果]在钯催化体系下目标产物的收率可达85.3%。[结论]此方法具有绿色环保、原料简单易得、反应效率高等特点。[Aims] The key intermediate of flometoquin’s derivatives was synthsized. [Methods] The targated product2-ethyl-3-methyl-6-[4-(trifluoromethoxy)phenoxy]quinoline was synthesized by substituted aniline and n-propanol as starting materials. [Results] The yield reached 85.3% under the palladium-catalyzed system. [Conclusions] The method featured benigh to environment, cheap starting materials and high efficiency.

关 键 词：flometoquin 喹啉 合成 

分 类 号：TQ460.3[化学工程—制药化工]