经前烦躁症肝气郁证方药脑区微观干预机制初探  

Preliminary Study on Microcosmic Intervention Mechanism of Prescription And Brain Area of PMDD Liver Qi Stagnation Syndrome

作　　者：张浩 胡明会[1,2] 高明周 魏盛 ZHANG Hao;HU Minghui;GAO Mingzhoul;WEI Sheng(College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,Shandong,China;Behavioral Phenotyping Core Facility,Shandong University of Traditional Chinese Medicine,Jinan 250355,Shandong,China)

机构地区：[1]山东中医药大学中医学院,山东济南250355 [2]山东中医药大学动物行为学实验平台,山东济南250355

出　　处：《辽宁中医杂志》2019年第1期212-214,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81573854)

摘　　要：经前烦躁症(PMDD)是经前期综合征(PMS)的严重类型,而PMDD肝气郁证是PMDD的重要亚型,症状广泛而复杂,发病率日渐增高,临床表现愈发严重,发病机理尚不明确,治疗效果差。然而国内外PMDD亚型的报道研究并不多,且缺乏统一的标准,探索PMDD亚型研究极为重要。目前该病的发病机制已经延伸到相关脑区,探索多种药物的作用靶点,揭示肝气郁证脑区功能变化,揭示其发病机制,更好的服务于临床。Premenstrual irritation(PMDD) is a serious type of premenstrual syndrome(PMS),and liver Qi stagnation sydnrome is an important subtype of PMDD.The symptoms are extensive and complex.The incidence is increasing and the clinical manifestation is more serious.The pathogenesis is still not clear.However,there are few reports on PMDD subtypes at home and abroad,and there is no uniform standard.It is very important to explore PMDD subtype research.At present,the pathogenesis of the disease has been extended to the relevant brain area.Exploring the role of a variety of drug targets,revealing the liver Qi stagnation of brain function changes and its pathogenesis,can better serve the clinic.

关 键 词：PMDD 方药 脑区 机制 

分 类 号：R256.4[医药卫生—中医内科学]