CD4^+ T细胞表位预测方法的研究进展  

Research progress of CD4^+ T cell epitope prediction methods

作　　者：李皖豫 余崴 李金钱 崔玉东[1] LI Wanyu;YU Wei;LI Jinqian;CUI Yudong(College of Life Science and Technology,HeiLongJiang BaYi Agricultural University,Daqing 163319,China)

机构地区：[1]黑龙江八一农垦大学生命科学技术学院,大庆163319

出　　处：《免疫学杂志》2019年第2期167-173,共7页Immunological Journal

基　　金：黑龙江省科学基金重点项目(ZD2016004);研究生创新科研项目(YJSCX2017-Y69)

摘　　要：CD4^+T细胞表位是指外源性抗原经过抗原提呈细胞加工后,由MHC-Ⅱ类分子提呈给初始CD4^+T细胞受体的短肽。在过去的20年中,随着分子免疫学技术和生物信息学技术的发展及应用,CD4^+T细胞表位的预测技术获得了较大的进展,其预测效率也在逐步提高,这对于减少实验合成重叠肽、研究抗原与机体作用的免疫机制以及研制蛋白质亚单位疫苗和表位疫苗等均有重要意义。本文就CD4^+T细胞表位预测的分子基础和CD4^+T表位生物信息学预测分析进行阐述。The CD4^+T cell epitope is a short peptide which refers to the exogenous antigen being taken up by the antigen-presenting cells, and presented to naive CD4^+T cell receptor by MHC class Ⅱ molecule, then successively initiates a CD4^+T cell immune response. In the past two decades, with the development and application of molecular immunology and bioinformatics technologies, great progress has been made in the prediction of CD4^+T cell epitope, and their predictive efficiency is gradually increasing. This is of great significance to reduce the experimental synthesis of overlapping peptides, to study the mechanism of antigen-induced immune response and to develop protein subunit vaccine and peptide vaccine. This review summarizes the molecular basis of CD4^+T cell epitope prediction and the progress in prediction methods.

关 键 词：CD4^+T细胞表位 MHC-Ⅱ类分子 预测方法 

分 类 号：R392.33[医药卫生—免疫学]