树突状细胞在变应性鼻炎免疫应答中的作用  

The role of dendritic cells in the immune response to allergic rhinitis

作　　者：熊培政 章刚 刘英[1] 孙亚宁 曾佐静 彭顺林[3] XIONG Peizheng;ZHANG Gang;LIU Ying;SUN Yaning;ZENG Zuojing;PENG Shunlin(Graduate School of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China;Department of Emergency,Sichuan Integrative Medicine Hospital,Chengdu 610041,China;Department of Otorhinolaryngology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075, China)

机构地区：[1]成都中医药大学研究生院,610072 [2]四川省中西医结合医院急诊科,成都610041 [3]成都中医药大学附属医院耳鼻喉科,610075

出　　处：《免疫学杂志》2019年第2期174-178,共5页Immunological Journal

基　　金：国家自然科学基金面上项目(81574034;81273812)

摘　　要：树突状细胞(DC)是公认为最有效的诱导适应性免疫应答的专职抗原呈递细胞,在变应性鼻炎发病机制中起着关键作用。DC通过病原体识别受体感知病原微生物的剌激,并解码、整合和递呈这些刺激产生的信号到T细胞,引起免疫应答。本文将从DC亚群和功能、过敏原识别到介导T细胞免疫应答及针对靶点DC的免疫疗法做系统性综述,以便于充分利用DC生物学知识为临床防治变应性鼻炎提供重要参考。Dendritic cells(DC) are recognized as the most effective professional antigen presenting cells to induce adaptive immune response and play a key role in the pathogenesis of allergic rhinitis. DCs sense microbial stimuli through pathogen-recognition receptors and decode, integrate, and present information derived from such stimuli to T cells, thus cause immune responses. In this paper, we will make a systematic review on DC subsets and their functions, allergen recognition, T cell immune response and targeting immunotherapy, in order to provide some references for clinical prevention and treatment of allergic rhinitis by making full use of DC biological knowledge.

关 键 词：树突状细胞 变应性鼻炎 免疫应答 共刺激分子 

分 类 号：R392.12[医药卫生—免疫学]