升清降浊汤联合重组人血管内皮抑制素腹腔灌注对恶性腹水患者血管内皮生长因子的影响  

Effect of Ascending Lucidity Descending Turbidity decoction combined with recombtnant human endostation intraperitoneal perfusion on vascular endothelial growth factor in patients with malignant ascites

作　　者：冯高飞 陈若 易舒婧 涂轩 刘鹏[1] 钟元涛 胡世平 FENG Gao-fei;CHEN Ruo;YI Shu-jing;TU Xuan;LIU Peng;ZHONG Yuan-tao;HU Shi-ping(Shenzhen Hospital,Beijing University of Chinese Medicine,Shenzhen 518172,China)

机构地区：[1]北京中医药大学深圳医院(深圳市龙岗区中医院),广东深圳518172

出　　处：《中国中西医结合消化杂志》2019年第1期36-39,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：深圳市龙岗区科技创新局(No:20170405192454916)

摘　　要：[目的]观察升清降浊汤联合重组人血管内皮抑制素腹腔灌注治疗恶性腹水的疗效及对血管内皮因子(VEGF)的影响。[方法]82例恶性腹水患者随机分为观察组42例和对照组40例,对照组采用重组人血管内皮抑制素腹腔灌注,观察组在此基础上加用升清降浊汤口服,共治疗4周。观察2组患者临床疗效、中医症状改善情况、KPS评分及腹水VEGF表达水平。[结果]观察组在临床疗效方面优于对照组(P<0.05),同时观察组在改善中医症状、KPS评分方面也优于对照组(P<0.05),观察组腹水VEGF表达水平较对照组降低,差异有统计学意义(P<0.05)。[结论]升清降浊汤联合重组人血管内皮抑制素腹腔灌注治疗恶性腹水效果显著,并可能通过下调VEGF表达来抑制肿瘤血管生长,减少腹水生成。[Objective]To observe the effect of Ascending Lucidity Descending Turbidity Decoction(ALDTD)combined with recombtnant human endostation on vascular endothelial growth factor(VEGF)of malignant ascites.[Methods]82 patients with malignant ascites were randomly divided into observation group(42 cases)and control group(40 cases).The control group was given Endostar intraperitoneal perfusion,and the observation group was given ALDTD and Endostar.The two groups were treated for 4 weeks.The clinical efficacy,improvement of TCM symptoms,KPS score and VEGF expression level of two groups were observed.[Results]The observation group was superior to the control group in clinical efficacy(P<0.05),and the observation group was superior to the control group in improving TCM symptoms and KPS scores(P<0.05).The expression of VEGF in ascites of the observation group was lower than control group(P<0.05).[Conclusion]ALDTD combined with Endostar intraperitoneal perfusion is effective in the treatment of malignant ascites,and may inhibit tumor angiogenesis and reduce ascites formation by down-regulating the expression of VEGF.

关 键 词：恶性腹水 升清降浊汤 重组人血管内皮抑制素 血管内皮生长因子 

分 类 号：R442.5[医药卫生—诊断学]