初治、复治肺结核患者细胞免疫功能与营养状况比较  

Cellular immune function and nutritional status in newly treated and retreated pulmonary tuberculosis patients

作　　者：王玉红[1] 王智慧[1] 李晓倩 杨帆[1] 梁亚充 谢兰品[1] WANG Yuhong;WANG Zhihui;LI Xiaoqian;YANG Fan;LIANG Yaehong;XIE Lanpin(Department of Medicine Ⅱ in Tuberculosis,Hebei Province Chest Hospital,Shijiazhang,Hebei 050041,China)

机构地区：[1]河北省胸科医院结核内二科,河北石家庄050041

出　　处：《中国热带医学》2019年第2期132-135,共4页China Tropical Medicine

基　　金：河北省科技计划项目(No.132777249)

摘　　要：目的探讨初治、复治肺结核患者细胞免疫功能与营养状况。方法选择2013年12月—2016年12月在河北省胸科医院进行治疗的200例肺结核患者的为研究对象,按照患者是否为初次治疗分为初治组和复治组,其中初治组117例,复治组83例,分析两组患者的细胞免疫和营养状况指标。结果复治组患者的CD3+、CD4+T细胞与CD4+/CD8+数值分别为(64.15±9.12)%、(35.21±6.37)%、(1.13±0.09)%,均低于初治组(71.07±8.07)%、(43.28±7.96)%、(1.52±0.13)%,而CD8+T细胞计数复治组(36.36±7.58)%高于初治组(28.55±6.89)%,差异均具有统计学意义(P<0.05);初治组患者的NK细胞、B淋巴细胞、IgG、IgA、IgM数值分别为(12.37±5.98)%、(12.41±7.74)%、(12.37±6.28)g/L、(2.13±0.26)g/L、(1.34±0.52)g/L,复治组为(11.89±6.38)%、(13.21±6.41)%、(13.35±7.24)g/L、(2.17±0.31)g/L、(91.42±0.45)g/L,两组比较差异均不具有统计学意义(P>0.05);复治组BMI、血红蛋白、总淋巴细胞计数和白蛋白数值分别(18.64±3.68)kg/m2、(110.36±15.57)g/L、(1.63±0.52)×109/L、(30.05±5.84)g/L,均低于初治组相应数值(20.34±3.58)kg/m2、(119.86±17.85)g/L、(1.92±0.61)×109/L、(34.25±6.31)g/L,差异均具有统计学意义(P<0.05)。结论初治与复治肺结核患者的细胞免疫功能指标在疾病的诊断、治疗和预后推断中有着重要意义,在进行临床诊断和治疗过程中,需要对此类指标进行监测。复治肺结核患者身体营养状况较差,需要在治疗过程中保证营养的摄入。Objective To investigate the comparison of cellular immune function and nutritional status between newlytreated and retreated patients with pulmonary tuberculosis. Methods A total of 200 pulmonary tuberculosis patients wereselected in Hebei Province Chest Hospital from December 2013 to December 2016. According to whether for the firsttreatment, the patients were divided into the initial treatment group 117 patients and retreatment group 83 patients. Cellularimmune and nutritional status indicators were analyzed of patients of the two groups. Results The level of CD3^+T cells, CD4^+T cells and CD4^+/CD8^+ in the retreatment group(64.15±9.12)%,(35.21±6.37)%,(1.13±0.09)% were lower than those in theinitial treatment group(71.07±8.07)%,(43.28±7.96)%,(1.52±0.13)%, and the level of CD8^+T cells were higher than those ofthe initial treatment group(28.55±6.89)%(P<0.05). The level of NK cells, B lymphocytes, IgG, IgA and IgM in the initialtreatment group(12.37±5.98)%,(12.41±7.74)%,(12.37±6.28)g/L,(2.13±0.26)g/L,(1.34±0.52)g/L and the retreatmentgroup(11.89 ± 6.38)%,(13.21 ± 6.41)%,(13.35 ± 7.24)g/L,(2.17 ± 0.31)g/L,(91.42 ± 0.45)g/L were not statisticallysignificant(P>0.05). BMI, hemoglobin, total lymphocyte count and albumin in the retreatment group(18.64±3.68)kg/m^2,(110.36±15.57)g/L,(1.63±0.52)×10^9/L,(30.05±5.84)g/L were lower than those in the initial treatment group(20.34±3.58)kg/m^2,(119.86 ± 17.85)g/L,(1.92 ± 0.61)× 10^9/L,(34.25 ± 6.31)g/L(P<0.05). Conclusion The initial treatment andretreatment of pulmonary tuberculosis patients with cellular immune function index in diagnosis of diseases, plays an importantrole in the treatment and prognosis of inference, in the process of clinical diagnosis and treatment, monitoring of such indicatorsis required. The nutritional status of the patients with retreatment TB is poor, so it is necessary to ensure the nutrition intakeduring the treatment.

关 键 词：肺结核 免疫功能 营养状况 

分 类 号：R521[医药卫生—内科学]