白驳丸加减方对稳定期白癜风患者治疗作用研究  

Therapeutic Effect of Modified Baibo Pills for Stable Vitiligo

作　　者：黄艳红 杨玉峰[2] 钟玲玲 刘少芬[2] 李婷[1] HUANG Yan-Hong;YANG Yu-Feng;ZHONG Ling-Ling;LIU Shao-Fen;LI Ting(The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen 518033 Guangdong,China;Shenzhen Municipal Hospital of Traditional Chinese Medicine,Shenzhen 518033 Guangdong,China)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]深圳市中医院,广东深圳518033

出　　处：《广州中医药大学学报》2019年第2期204-209,共6页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】观察口服白驳丸加减方对稳定期白癜风患者临床疗效的影响。【方法】将50例初次就诊于深圳市中医院皮肤科并确诊为稳定期白癜风患者随机分为治疗组26例和对照组24例。2组均给予外涂复方补骨脂酊治疗,治疗组同时给予口服白驳丸加减方治疗,对照组同时给予口服转移因子胶囊治疗,疗程6个月。观察2组患者治疗前后白斑面积、色素评分及中医证候评分的变化情况,并评价2组疗效和安全性。【结果】(1)经过6个月治疗后,治疗组的总有效率为84.62%,对照组为41.67%,治疗组的总有效率和总体疗效均优于对照组,差异均有统计学意义(P<0.05)。(2)治疗后,2组患者的白斑面积均较治疗前缩小,色素评分及中医证候评分(包括主症评分、次症评分及总评分)均较治疗前降低(P<0.05),且治疗组在缩小白斑面积、降低色素评分和中医证候评分方面均优于对照组(P<0.05)。(3)研究过程中,2组患者均无明显的不良反应事件发生。【结论】在外涂复方补骨脂酊的基础上口服白驳丸加减方治疗稳定期白癜风,具有较好疗效,能有效缩小白斑面积,改善患者中医证候,其疗效明显优于口服转移因子胶囊。Objective To observe the clinical efficacy of oral use of modified Baibo Pills for the treatment of stable vitiligo.Methods Fifty patients who first visited Department of Dermatology in Shenzhen Municipal Hospital of Traditional Chinese Medicine and were diagnosed as stable vitiligo were randomized into treatment group(n=26)and control group(n=24).Both groups were given external application of Compound Psoralen Tincture,and additionally the treatment group was given oral use of modified Baibo Pills and the control group was given oral use of Transfer Factor Capsules.The treatment course of the two groups lasted for 6 months.Before and after treatment,the vitiligo area,pigment scores,and traditional Chinese medicine(TCM)symptom scores in the two groups were examined.After treatment,the clinical efficacy and safety of the two groups were compared.Results(1)After treatment for 6 months,the total effective rate in the treatment group was 84.62%,and that in the control group was 41.67%,the total effective rate and overall efficacy of the treatment group being superior to that of the control group(P<0.05).(2)The vitiligo area,pigment scores and TCM symptom scores(including primary symptom scores,secondary symptom scores and overall scores)in the two groups were decreased(P<0.05 compared with those before treatment),and the decrease in the treatment group was superior to that in the control group(P<0.05).(3)During the treatment,no obvious adverse reaction was shown in the two groups.Conclusion On the basis of external use of Compound Psoralen Tincture,oral use of modified Baibo Pills is more effective in treating stable vitiligo than oral use of Transfer Factor Capsules by shortening vitiligo area and relieving TCM symptoms.

关 键 词：稳定期白癜风 白驳丸加减方 转移因子胶囊 复方补骨脂酊 临床疗效 

分 类 号：R275.9[医药卫生—中西医结合] R758.41[医药卫生—中医皮科]