青中年正常高值血压伴高胆固醇血症患者血浆big ET-1水平及综合干预对其的影响  

Plasma levels of big ET-1 in patients with normal high blood pressure and hypercholesterolemia in young and middle-aged patients and the effect of comprehensive intervention on their levels

作　　者：寿晓玲[1] 周蓉芳[1] 王磊[1] 朱利月[2] 王伯忠[1] 任爱华[1] SHOU Xiao-ling;ZHOU Rong-fang;WANG Lei(Department of Cardiac Rehabilitation,the Hospital of Zhejiang,Hangzhou,Zhejiang 310013,China)

机构地区：[1]浙江医院心脏康复科,浙江杭州310013 [2]浙江医院康复治疗中心

出　　处：《中华全科医学》2019年第2期216-218,340,共4页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2012KYA010);浙江省医药卫生科技计划项目(2014KYA005);浙江省中医药科技计划项目(2013ZB015);浙江省科技厅公益技术应用研究计划项目(2016C33123)

摘　　要：目的探讨综合干预对青中年正常高值血压伴高胆固醇血症患者血浆大内皮素-1(big endothelin-1,big ET-1)水平的影响,并探讨其临床意义。方法选择浙江医院2012年10月—2014年12月符合标准的青中年正常血压者200例作为对照组,青中年正常高值血压伴高胆固醇血症患者200例作为观察组。观察组患者给予综合干预。采用全自动生化分析仪测定患者甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)水平;采用酶联免疫吸附测定(ELISA)法测定血浆big ET-1水平。结果观察组患者收缩压、舒张压及TC、TG、LDL-C、big ET-1水平高于对照组(均P<0.05)。综合干预后各时间点收缩压、舒张压、TC、TG、LDL-C、big ET-1水平均低于干预前(均P<0.05);随着干预时间延长,收缩压、舒张压、TC、TG、LDL-C、big ET-1水平不断降低,各时间点之间比较差异均有统计学意义(P<0.05)。收缩压、TC、HDL-C为血浆big ET-1水平的影响因素(均P<0.05)。结论青中年正常高值血压伴高胆固醇血症患者血浆big ET-1水平明显升高,综合干预可降低患者血浆big ET-1水平,对预防内皮功能损伤具有重要意义。Objective To explore the effect of comprehensive intervention on plasma big ET-1 Level in normal middleaged patients of normal high blood pressure with hypercholesterolemia.Methods Two hundred patients with normal blood pressure were selected as the control group,and 200 patients with normal high blood pressure were selected as the observation group from October 2012 to December 2014 in Zhejiang Hospital.Patients in the observation group were given comprehensive intervention.The levels of triglycerides(TG),total cholesterol(TC),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C) level were measured by automatic biochemical analyzer.The level of plasma big ET-1was determined by enzyme-linked immunosorbent assay(ELISA).Results The systolic and diastolic blood pressure and the levels of TC,TG,LDL-C,big ET-1 in the observation group were higher than those in the control group(all P <0.05).After intervention,the systolic blood pressure,diastolic blood pressure,TC,TG,LDL-C,and big ET-1 levels at various time points were lower than those before intervention(all P < 0.05).With the prolongation of the intervention time,the systolic blood pressure,diastolic blood pressure,TC,TG,LDL-C and big ET-1 levels continued to decrease,and there were statistically significant differences among the time points(all P < 0.05).Systolic blood pressure,TC and HDL-C were the influencing factors of plasma big ET-1(all P < 0.05).Conclusion The level of plasma big ET-1 in patients with normal high blood pressure with hypercholesterolemia is significantly higher.Comprehensive intervention can reduce the plasma ET-1 levels of the patients,and has great significance on the prevention of endothelial dysfunction.

关 键 词：生活方式 药物 正常高值血压 高胆固醇血症 大内皮素-1 

分 类 号：R443.5[医药卫生—诊断学] R589.2[医药卫生—临床医学]