骨质疏松性椎体骨折患者血清破骨细胞生成抑制因子和破骨细胞分化因子的表达及意义  

Expression and significance of osteoclastogenesis inhibitory factor and osteoclast differentiation factor in patients with osteoporotic vertebral fracture

作　　者：占允中[1] 叶舟[1] 占蓓蕾[1] 张俊超 ZHAN Yun-zhong;YE Zhou;ZHAN Bei-lei(Department of Orthopedics,Quzhou City People's Hospital,Quzhou,Zhejiang 324000,China)

机构地区：[1]衢州市人民医院骨科,浙江衢州324000

出　　处：《中华全科医学》2019年第1期73-75,共3页Chinese Journal of General Practice

基　　金：浙江省科学技术厅公益性技术研究社会发展项目(2015C33294)

摘　　要：目的探讨骨质疏松性椎体骨折患者血清破骨细胞生成抑制因子(osteoclast suppressor,OCIF)和破骨细胞分化因子(osteoclast differentiation factor,ODF)的表达及意义。方法选择衢州市人民医院2013年1月—2016年12月符合标准的骨质疏松性椎体骨折患者70例为骨质疏松组,非骨质疏松性椎体骨折患者70例为对照组。采用双抗体夹心酶联免疫吸附实验(Double antibody sandwich enzyme-linked immunosorbent assay,ELISA)法测定血清OCIF和ODF水平。采用双能X线骨密度仪测量腰椎正位总体L1～4骨密度及左侧股骨颈骨密度。采用SPSS20. 0统计软件对数据进行分析。结果骨质疏松组血清OCIF和ODF水平均高于对照组(均P <0. 05)。骨质疏松组腰椎正位骨密度和股骨颈骨密度均低于对照组(均P <0. 05)。骨质疏松患者血清OCIF、ODF水平与腰椎正位骨密度、股骨颈骨密度均呈负相关(均P <0. 05)。骨质疏松患者血清OCIF、ODF水平与骨折程度无显著相关性(均P> 0. 05)。结论骨质疏松性椎体骨折患者血清OCIF、ODF水平升高,血清OCIF、ODF水平与骨质疏松性椎体骨折患者的骨密度关系密切,与骨折的严重程度关系不大。Objective To investigate the expression and significance of osteoclastogenesis inhibitory factor( OCIF) and osteoclast differentiation factor( ODF) in patients with osteoporotic vertebral fractures. Methods Total 70 cases of osteoporotic vertebral fractures were selected as osteoporosis group,and 70 cases of non-osteoporotic vertebral fractures were selected as control group in Quzhou People’ s Hospital from January 2013 to December 2016. The serum levels of OCIF and ODF were tested by double antibody sandwich enzyme-linked immunosorbent assay( ELISA). Dual-energy X-ray absorptiometry was used to measure the total L1-4bone mineral density in the lumbar spine and left femoral neck. The SPSS20. 0 software was used to analyze the data. Results The levels of serum OCIF and ODF in the osteoporosis group were higher than those in the control group( all P < 0. 05). The lumbar spine bone mineral density and femoral neck bone mineral density in the osteoporosis group were lower than those in the control group( all P < 0. 05). The serum OCIF,ODF in the osteoporosis group were negatively correlated with lumbar spine bone mineral density and femoral neck bone mineral density( all P < 0. 05). The serum OCIF and ODF levels in patients with osteoporosis had no significant correlation with the degree of fracture( all P > 0. 05). Conclusion The serum OCIF and ODF levels increase obviously in the patients with osteoporotic vertebral fractures,and closely related to the bone mineral density,and not with the severity of the fracture.

关 键 词：骨质疏松 椎体骨折 破骨细胞生成抑制因子 破骨细胞分化因子 

分 类 号：R683.2[医药卫生—骨科学]