α-细辛脑亚微乳经静脉与灌胃给药的药动学比较  

Comparison study on the pharmacokinetics of α-asarone submicroemulsion between intravenous and gavage

作　　者：丁宁 孙士力 程睿颖 邹慧熹 廖芯[2] 毛声俊[1] DING Ning;SUN Shili;CHENG Ruiying;ZOU Huixi;LIAO Xin;MAO Shengjun(Key Laboratory of Drug Targeting and Drug delivery System,Ministry of Education,West China School of Pharmacy,Sichuan University,Chengdu ,Sichuan ,610041 P.R.China;West China Second Hospital,Sichuan University,Chengdu ,Sichuan ,610041 P.R.China)

机构地区：[1]四川大学华西药学院靶向药物及释药系统教育部重点实验室,四川成都610041 [2]四川大学华西第二医院,四川成都610041

出　　处：《华西药学杂志》2019年第1期55-57,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的考查α-细辛脑亚微乳经不同途径给药后的药动学性质,为确定适宜的给药途径提供依据。方法分别采用静脉注射和灌胃两种方式给予SD大鼠50 mg·kg-1α-细辛脑亚微乳;以HPLC法测定血浆中α-细辛脑的含量;采用DAS 2. 0软件分析药动学数据。结果α-细辛脑亚微乳经两种不同途径给药后的血药浓度-时间曲线均符合二室模型;与静脉注射组比较,灌胃给药组的绝对生物利用度约68. 5%。结论α-细辛脑亚微乳经灌胃给药的绝对生物利用度较高,可作为适宜的给药途径。OBJECTIVE To compare the pharmacokinetics of α-asarone submicroemulsion administered in different routesand to provide the basis for determining its appropriate route of administration. METHODS Self-prepared α-asaronesubmicroemulsion was given to SD rats by intravenous injection and gavage at a dose of 50 mg·kg-1 respectively. The contents ofα-asarone in the plasma of rats were determined by HPLC. Pharmacokinetic parameters and oral bioavailability were calculatedusing DAS 2. 0 software. RESULTS The plasma concentration-time curves of the two routes conform to the two-compartmentmodel. Compared to the intravenous administration,the absolute bioavailability of gavage administration was about 68. 5%.CONCLUSION Gavage administered α-asarone submicroemulsion has been proved a relatively high absolute bioavailability,which can be used as an appropriate way of administration.

关 键 词：Α-细辛脑 亚微乳 给药途径 静脉注射 灌胃 血药浓度 药动学 生物利用度 高效反液相色谱法 药时曲线 

分 类 号：R969[医药卫生—药理学]