Synthesis, Crystal Structure and Biological Evaluation of 6'-Chloro-4'-methylene-3H-spiro[isobenzofuran-1,3'-isochroman]  

作　　者：PU Xiu-Ying XU Wen-Jun YI Yun-Peng LI Hao-Wen LIANG Jian-Ping HAO Bao-Cheng PU Xiu-Ying;XU Wen-Jun;YI Yun-Peng;LI Hao-Wen;LIANG Jian-Ping;HAO Bao-Cheng(School of Life Science and Engineering, Lanzhou University of Technology;Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture,Institute of Husbandry and Pharmaceutical Sciences of CAAS)

机构地区：[1]School of Life Science and Engineering, Lanzhou University of Technology [2]Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture,Institute of Husbandry and Pharmaceutical Sciences of CAAS

出　　处：《Chinese Journal of Structural Chemistry》2019年第1期89-94,3,共7页结构化学（英文）

基　　金：National Key Technology Support Program(No.2015BAD11B02);Agricultural Science and Technology Innovation Program(ASTIP,No.CAASASTIP-2014-LIHPS-04)

摘　　要：The title compound 6?-chloro-4?-methylene-3 H-spiro [isoben zofura-1,3?-isochroman], C_(17)H_(13)ClO_2, was prepared and characterized by IR, NMR, HRMS and single-crystal X-ray diffraction. This compound has a bisbenzannulated [5,5]-spiroketals skeleton. It crystallizes in orthorhombic, space group P212121 with a = 13.383(3), b = 7.6120(17), c = 13.793(3) ?, Z = 4, Dc= 1.275 g/cm^3, μ = 0.28 mm^(–1), F(000) = 592, wR = 0.1443 and R = 0.0557. The preliminary biological test showed that the title compound has good anti-bacterial activities in vitro.

关 键 词：3H-spiro[isobenzofura-1 3'-isochroman] single-crystal structure ANTI-BACTERIAL 

分 类 号：TQ[化学工程]