皮质脑电图静息态慢皮质电位术中定位运动区皮质的方法研究  

The ERP of slow cortial potential resting-state networks from ECoG in intraoperative mapping of motor related cortices

作　　者：周思捷 姜涛 王伟民 王国良 夏丽慧 刘永超 吴效明 朱小艳 白红民 Zhou Sijie;Jiang Tao;Wang Weimin;Wang Guoliang;Xia Lihui;Liu Yongchao;Wu Xiaoming;Zhu Xiaoyan;Bai Hongmin(Department of Neurosurgery ,General Hospital of Southern Theatre Command,Guangzhou 510010,China;South China University of Technology School of Materials Science and Engineering,Guangzhou 510006,China;Department of Neurosurgery,The First People's Hospital of Foshan,Foshan 528000,China)

机构地区：[1]中国人民解放军南部战区总医院神经外科,广州510010 [2]华南理工大学材料科学与工程学院生物医学工程系,广州510006 [3]佛山市第一人民医院神经外科,广东528000

出　　处：《中华神经外科杂志》2019年第1期59-62,共4页Chinese Journal of Neurosurgery

基　　金：“863”国家高新技术研究发展计划(201AA020504);广东省科技计划项目(2014A020215005,20178020210008);军队后勤科研计划(CGZ163J003).

摘　　要：目的探讨通过皮质脑电图(ECoG)静息态慢皮质电位分析定位脑运动区皮质的可行性。方法回顾性纳入2014年12月至2016年6月解放军广州总医院神经外科收治的13例脑功能区病变患者,均在术中唤醒状态下手术,术中采用皮质直接电刺激(DES)定位运动区皮质。采集并分析静息状态下的ECoG信号,评价其定位运动区皮质的灵敏性和特异性。结果术中所有患者均通过DES完成对运动区皮质的定位,在静息状态下可见ECoG慢皮质电位的事件相关电位变化最明显,以1.6阈值为特征值,与DES对比,ECoG定位有较高的灵敏性(90.6%)和中等的特异性(59.2%)。结论ECoG静息态慢皮质电位分析可用于术中定位运动区皮质,有望成为术中辅助DES定位的一种新方法。Objective To explore the sensitivity and specificity of electrocorticography (ECoG) in intraoperative mapping of motor cortices with the event-related potential (ERP) of slow cortical potential resting-state networks. Methods Thirteen patients with brain lesions near eloquent areas who were admitted to Department of Neurosurgery, Guangzhou General Hospital of Guangzhou Military Command from December 2014 to June 2016 were treated under awake craniotomy. The motor-related cortices were detected by intraoperative direct electrical stimulation. The ECoG were collected from patients in resting state. The ERP of slow cortical potential resting-state networks was analyzed. The sensitivity and specificity of ECoG in mapping of motor cortices were evaluated. Results Motor areas were identified by DES in all patients. The ERP of slow cortical potential resting-state networks was significant and regarded as the specific rhythm of motor cortex. When the threshold of ERP of the specific rhythm was chosen as 1.6, this method showed the optimal sensitivity (90.6%) and modest specificity (59.2%) compared with the other threshold. Conclusion Data analysis of the ERP of slow cortical potential resting-state networks from ECoG can be used to map motor areas intraoperatively, which is expected as a new adjunct to DES for intraoperative mapping.

关 键 词：脑疾病 皮质脑电图 慢皮质电位 运动区皮质定位 

分 类 号：R651.1[医药卫生—外科学]