青少年Chiari畸形合并脊髓空洞患者后颅窝减压术后空洞转归与颈椎矢状面形态改善的相关性  

Correlation between syrinx resolution after posterior fossa decompression and cervical sagittal profile change in adolescents with Chiari malformation and syringomyelia

作　　者：江龙[1] 夏超 朱卫国 史本龙 刘臻[1] 邱勇[1] 朱泽章[1] Jiang Long;Xia Chao;Zhu Weiguo;Shi Benlong;Liu Zhen;Qiu Yong;Zhu Zezhang(Department of Spinal Surgery,Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210008,China)

机构地区：[1]南京医科大学鼓楼临床医学院脊柱外科,南京210008

出　　处：《中华医学杂志》2019年第3期183-187,共5页National Medical Journal of China

基　　金：国家自然科学基金面上项目(81772304).

摘　　要：目的研究青少年Ⅰ型Chiari畸形(CMI)/脊髓空洞后颅窝减压(PFD)术后远期颈椎矢状面形态,并探讨其与脊髓空洞转归的相关性。方法回顾性分析2011年10月至2015年8月南京鼓楼医院脊柱外科收治的32例接受标准PFD术且随访超过2年的CMI/脊髓空洞患者的影像学资料。其中男23例,女9例。年龄为10~16岁,平均(13.7±2.8)岁。比较术前及末次随访时颈椎矢状面参数及空洞参数的变化:上颈椎角(C0-C2)、下颈椎角(C2-C7)、颈椎矢状面平衡(C2-C7SVA)、颈椎曲率指数(CCI)、空洞直径及空洞长度;并用Pearson相关分析检测空洞直径及长度的改变与颈椎矢状面参数间的相关性。结果随访时间2.0~6.5年,平均(3.9±1.1)年。末次随访时下颈椎角及CCI分别为-29.8°±11.4°和29.1%±7.1%,均较术前(-15.2°±8.8°,13.4%±4.2%)显著增加,差异均有统计学意义(t=2.917、2.902,均P<0.05)。末次随访时空洞直径及长度则较术前明显减小。术前与末次随访时C0-C2及C2-C7SVA差异无统计学意义(t=0.302、0.871,均P>0.05)。手术前后空洞直径减小与下颈椎角及CCI的变化呈正相关(r=0.611、0.652,均P<0.05),空洞长度减小亦与下颈椎角及CCI的变化呈正相关(r=0.504、0.514,均P<0.05)。结论青少年CMI/脊髓空洞患者PFD术后颈椎前凸得以恢复,脊髓空洞的改善可能是颈椎矢状面形态重塑的重要因素。Objective To evaluate the long term change of the cervical sagittal profile in adolescent Chiari malformation type Ⅰ (CMI)/syringomyelia undergoing posterior fossa decompression (PFD) and to further evaluate the correlation between the syrinx resolution and cervical sagittal profile. Methods A retrospective radiographic study was performed in 32 adolescents undergoing PFD for CMI/syringomyelia from October 2011 to August 2015 with a minimum 2-year follow-up. There were 23 males and 9 females, with a mean age of (13.7±2.8) years (range, 10-16 years). The following parameters including upper cervical angle (C0-C2), lower cervical angle (C2-C7), sagittal balance (C2-C7SVA), cervical curvature index (CCI), syrinx size and length were compared preoperatively and at the last follow-up. The correlation of syrinx resolution and cervical sagittal parameters were further analyzed with Pearson correlation analysis. Results All patients received a followed-up for 2.0-6.5 years [mean (3.9±1.1) years]. The lower cervical angle and CCI were-29.8°±11.4° and 29.1%±7.1% at the last follow-up, respectively, which were significantly higher than those before surgery (-15.2°±8.8°, 13.4%±4.2%)(t=2.917, 2.902, both P<0.05). The syrinx size and length were also obviously decreased at the last follow-up. No significant difference was found in the upper cervical angle and C2-C7SVA before operation and at the last follow-up (t=0.302, 0.871, both P>0.05). There were significantly positive correlations between the differences of syrinx width and the lower cervical angle, and the CCI before and after surgery (r=0.611, 0.652, both P<0.05). Significantly positive correlations were also observed between the differences of syrinx length and the lower cervical angle, and the CCI before and after surgery (r=0.504, 0.514, both P<0.05). Conclusions The cervical lordosis can be restored after PFD in adolescents with CMI/syringomyelia. The resolution of syrinx may play an important role in restoring the cervical sagittal alignment.

关 键 词：Chili畸形 脊髓空洞 后颅窝减压术 颈椎 

分 类 号：R726.5[医药卫生—儿科]