艾蒿花粉过敏患者呼出一氧化氮及肺功能相关性研究  

Studies on the correlation between FeNO and Pulmonary ventilation function in patients with mugwort pollen allergy

作　　者：邵婵 何雪梅 魏庆宇 SHAO Chan;HE Xuemei;WEI Qingyu(the 2016th Graduate,China Medical University,Shenyang, Liaoning,110003,China;Department of Allergy,China Medical University NO.202 Hospital,Shenyang,Liaoning, 110003,China)

机构地区：[1]中国医科大学,2016级研究生辽宁沈阳110003 [2]中国医科大学第二○二医院变态反应科,辽宁沈阳110003

出　　处：《中国耳鼻咽喉头颈外科》2019年第1期45-47,共3页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：辽宁省自然科学基金资助项目(201602753)

摘　　要：目的了解在艾蒿过敏患者中,呼出一氧化氮(fractional exhale nitric oxide,FeNO)与肺功能是否具有相关性,病程、鼻炎评分与FeNO和肺功能是否具有相关性。方法对2018年8～9月间就诊的88例艾蒿花粉过敏患者的FeNO和肺功能结果进行统计分析。结果病程﹤5年的患者与病程≥9年的患者相比,FeNO和第1秒用力呼气容积占预计值百分比(FEV_1%)差异具有统计学意义(P=0.004,P=0.032),且随着病程的延长FeNO也相应增高,而FEV_1%则逐渐下降。FeNO与FEF_(25%-75%)占预计值百分比(FEF_(25%-75%pred))、FEV_1%呈负相关,而与FEV1占预计值百分比(FEV_1%pred)无相关性。鼻炎评分与FeNO呈正相关;与FEV_1%pred、FEV1%、FEF25%-75%pred无相关性。结论随着艾蒿过敏患者病情进展,其气流受限的几率也相应增大;FeNO在一定程度上可以早期预测气道功能的改变,能够作为哮喘预测的监测指标;FeNO值可以反应出机体炎症程度,可用于变应性鼻炎患者病情严重程度的辅助诊断。OBJECTIVE To investigate the correlation between fractional exhaled nitric oxide(FeNO)and lung function in artemisia argyi allergy patients.Whether the course of disease and rhinitis score are correlated with FeNO and lung function. METHODS A total of 88 patients with mugwort pollen allergy, who visited the hospital between August and September 2017 and August and September 2018, the results of their FeNO and Pulmonary ventilation function, were included in this study.RESULTS Compared with patients with a duration of 9 years or more, FeNO and FEVi% of patients with a duration of 5 years were significantly different(P=0.004,P=0.032),and FeNO increased with the extension of the duration,while FEV1% decreased gradually. FeNO was negatively correlated with FEF25%-75%pred and FEV1%,while there was no correlation with FEV1%Pred. Rhinitis score was positively correlated with FeNO. There was no correlation with FEV1%pred, FEV1%, FEF25%-75%pred. CONCLUSION With the development of mugwort pollen allergy, the probability of airflow limitation is also increased. To some extent, FeNO can predict the changes of airway function early, and can be used as a monitoring indicator for asthma prediction.FeNO value can reflect the degree of inflammation of the body,and can be used in the auxiliary diagnosis of the severity of allergic rhinitis patients.

关 键 词：鼻炎 变应性 季节性 蒿属 一氧化氮 呼吸功能试验 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]