Enhancement strategies of targetability, response and photostability for in vivo bioimaging  

作　　者：Kaizhi Gu Wei-Hong Zhu Xiaojun Peng 

机构地区：[1]Shanghai Key Laboratory of Functional Materials Chemistry, Key Laboratory for Advanced Materials and Institute of Fine Chemicals, Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center,School of Chemistry and Molecular Engineering, East China University of Science & Technology [2]State Key Laboratory of Fine Chemicals, Dalian University of Technology

出　　处：《Science China Chemistry》2019年第2期189-198,共10页中国科学（化学英文版）

基　　金：supported by National Natural Science Foundation of China for Science Center Program (21788102);National Key Research and Development Program (2016YFA0200300);Natural Science Foundation of China (21636002);National Postdoctoral Program for Innovative Talents (BX201700075)

摘　　要：Analyses of the physiology and pathology of active biochemical species in their native contexts are critical for early diagnosis and therapy. Optical imaging has emerged as one of the promising modalities for noninvasive and real-time visualization of important biomolecules or biological events, and it has witnessed major advances in the field of imaging in vitro and in vivo. In this review, we present a survey of common approaches and tactics for enhanced targetability, response rate, and photostability in bioimaging applications. Recently developed and representative examples are illustrated on the cellular and tissue levels.Analyses of the physiology and pathology of active biochemical species in their native contexts are critical for early diagnosis and therapy. Optical imaging has emerged as one of the promising modalities for noninvasive and real-time visualization of important biomolecules or biological events, and it has witnessed major advances in the field of imaging in vitro and in vivo. In this review, we present a survey of common approaches and tactics for enhanced targetability, response rate, and photostability in bioimaging applications. Recently developed and representative examples are illustrated on the cellular and tissue levels.

关 键 词：FLUORESCENT PROBE BIOIMAGING targetability RESPONSE rate PHOTOSTABILITY 

分 类 号：O6[理学—化学]