Synthesis of 4H-chromenes by silver(Ⅰ)-catalyzed cycloaddition of ortho-quinone methides with N-allenamides  

作　　者：Long Kong Nuligonda Thirupathi Jiong Jia Zhenghu Xu 

机构地区：[1]Key Laboratory for Colloid and Interface Chemistry of Education Ministry, Department of Chemistry, Shandong University [2]State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

出　　处：《Science China Chemistry》2019年第1期80-86,共7页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21572118,21750110444);the Natural Science Foundation of Shandong Province(ZR2018MB010);subject construction funds(104.205.2.5);Tang scholar award of Shandong University

摘　　要：Chromenes represent an important class of six-membered heterocycles and have drawn tremendous attention in recent years. In this article, we report a convenient and practical synthesis of this heterocycle by a silver(I)-catalyzed cycloaddition reaction between in situ generated ortho-quinone methides and N-allenamides. Diverse 4H-chromenes were synthesized in good to excellent yields under very mild conditions.Chromenes represent an important class of six-membered heterocycles and have drawn tremendous attention in recent years. In this article, we report a convenient and practical synthesis of this heterocycle by a silver(I)-catalyzed cycloaddition reaction between in situ generated ortho-quinone methides and N-allenamides. Diverse 4H-chromenes were synthesized in good to excellent yields under very mild conditions.

关 键 词：4H-chromene ortho-quinone methide N-allenamide silver-catalysis CYCLOADDITION 

分 类 号：O6[理学—化学]