HA-CaCO_3纳米复合凝胶的制备及性能表征  

Preparation and characterization of HA-CaCO_3 nano composite hydrogel

作　　者：华晓斌 徐菊美[1] 岑莲[1] HUA Xiao-bin;XU Ju-mei;CEN Lian(East China University of Science and Technology,Shanghai 200237,China)

机构地区：[1]华东理工大学,上海200237

出　　处：《现代化工》2019年第1期123-127,共5页Modern Chemical Industry

摘　　要：由于透明质酸(hyaluronic acid,HA)水凝胶的机械强度较弱,使其应用受到一定限制。以HA为原料、1,4-丁二醇二缩水甘油醚(1,4-butanediol diglycidyl ether,BDDE)为交联剂对HA进行交联制备HA凝胶,并在交联的同时用浸泡法在凝胶内复合碳酸钙(CaCO_3),以期形成力学性能优异的HA-CaCO_3复合凝胶。利用扫描电镜、红外光谱仪、热重分析仪和X射线衍射仪等对HA凝胶和HA-CaCO_3复合凝胶进行表征和分析,考察CaCO_3对HA凝胶的影响。结果表明,该方法制备的HA-CaCO_3复合凝胶的断裂伸长率达到401%,是单纯HA凝胶的2. 73倍。HA-CaCO_3复合凝胶中CaCO_3的质量分数为27. 3%,晶型为方解石,尺寸在30～80 nm,达到了纳米级别。HA-CaCO_3复合凝胶以其优异的力学性能进一步拓展了HA类凝胶的应用。Hyaluronic acid( HA) hydrogel is an ideal biomedical material due to its biocompatibility,biodegradability,biological activity and no immunogenicity.However,the application of HA hydrogel has been limited due to its weak mechanical strength.Herein,1,4-butanediol diglycidyl ether( BDDE) is employed as a crosslinking agent for HA to prepare HA hydrogel.While it is cross linking,CaCO3 is composited into HA hydrogel through soaking method for the purpose of fabricating HA-CaCO3 composite hydrogel with excellent mechanical properties. The properties of HA hydrogel and HA-CaCO3 nanocomposite hydrogel are characterized by scanning electron microscope,infrared spectrometer,thermo gravimetric analyzer and X ray diffractometer to investigate the influence of CaCO3 on HA hydrogel.The results indicate that the elongation at break of composite hydrogel reaches 401%,2. 73 times that of HA hydrogel.The mass fraction of CaCO3 in composite hydrogel is 27. 3%,CaCO3 exhibits calcite crystal form with sizes between 30-80 nm.Hence,by means its excellent mechanical properties,HA-CaCO3 composite hydrogel is expected to further extend the application scope of HA hydrogel.

关 键 词：透明质酸 CACO3 凝胶 机械强度 方解石 

分 类 号：TQ314.1[化学工程—高聚物工业]