牙髓干细胞多向分化潜能的研究及应用进展  

Study and application of multidirectional differentiation potential of dental pulp stem cells

作　　者：葛芳 杜立群[1] GE Fang;DU Liqun(Department of Ophthalmology,Qilu Hospital of Shandong University,Jinan 250012,P.R.China)

机构地区：[1]山东大学齐鲁医院眼科,济南250012

出　　处：《生物医学工程学杂志》2019年第1期172-176,共5页Journal of Biomedical Engineering

基　　金：山东省自然科学基金面上项目(ZR2015HM050)

摘　　要：牙髓干细胞(DPSCs)是一类成体干细胞,具有较强的增殖能力、自我更新能力、多向分化潜能,且来源丰富、获取方便、不涉及伦理问题,其作为种子细胞已在组织工程和再生医学领域发挥了重要作用,展现了巨大的潜能,有望成为组织修复和器官再生的理想种子细胞来源。DPSCs在骨再生领域的研究已应用到临床,而向其他组织的分化研究尚处于不同水平的基础阶段,本文就其在成牙、成骨、成神经等方向分化潜能的相关研究及应用作一综述,为DPSCs在组织工程和再生医学领域的进一步研究提供线索和思路。Dental pulp stem cells(DPSCs) are adult stem cells with strong proliferative ability,self-renewal ability and multidirectional differentiation potential.DPSCs have abundant source are easy to obtain,and do not have ethical problems.As seed cells,they played an important role and showed great potential in tissue engineering and regenerative medicine,making them potential ideal seed cells for repairation and regeneration of tissue and organ.Clinical application of DPSCs in bone regeneration has already been achieved,and studies on differentiation of DPSCs into other tissues are still at different levels of basic stage.In this paper,the research and application of directional differentiation potential such as tooth formation,osteogenesis,and nerve formation are reviewed in order to provide clues and ideas for further study on DPSCs in the field of tissue engineering and regenerative medicine.

关 键 词：牙髓干细胞 分化 组织工程 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]