髓鞘碱性蛋白、神经元特异性烯醇化酶在支原体肺炎并发脑炎患儿中的临床研究  

Clinical study of myelin basic protein and neuron-specific enolase in children with mycoplasmal pneumouniae pneumounia complicated with encephalitis

作　　者：李芹[1] 王亚坤[1] 田利远[1] 张曼[1] 王艳艳[1] 李清涛[1] 常海霞[1] LI Qin;WANG Ya-kun;TIAN Li-yuan;ZHANG Man;WANG Yan-yan;LI Qing-tao;CHANG Hai-xia(Department of Respiratory,Children's Hospital of Hebei Province,Shijiazhuang,Hebei 050031,China)

机构地区：[1]河北省儿童医院呼吸一科,河北石家庄050031

出　　处：《中国儿童保健杂志》2019年第2期202-204,共3页Chinese Journal of Child Health Care

基　　金：2018年度河北省医学科学研究重点课题计划(20180625)

摘　　要：目的测定脑脊液中髓鞘碱性蛋白(MBP)及神经元特异性烯醇化酶(NSE)的含量,探讨其在支原体肺炎并发脑炎患儿中的临床价值。方法 2016年4月-2017年10月选取68例支原体肺炎合并脑炎的患儿为实验组(包括非惊厥组36例,惊厥组32例),30例支原体肺炎患儿为对照组;采用ELISA方法检测脑脊液MBP、NSE的含量。结果惊厥组、非惊厥组患儿脑脊液MBP、NSE水平均显著高于对照组(P<0.05),且惊厥组均明显高于非惊厥组(P<0.05)。结论脑脊液MBP、NSE含量可作为评估支原体肺炎并发脑炎患儿中枢神经系统损伤及损伤程度的指标,这有助于临床医生及早判断病情和合理诊治。Objective To test the levels of myelin basic protein(MBP)and neuron-specific enolase(NSE)in the cerebrospinal fluid(CSF)of children with mycoplasmal pneumonia complicated with encephalitis,in order to explore the clinical value of MBP and NSE in the assessment of mycoplasmal pneumonia complicated with encephalitis. Methods Totally 68 cases with mycoplasmal pneumonia complicated with encephalitis were selected as experimental group(including 36 cases of non-convulsion group,32 cases of convulsion group)and 30 cases of mycoplasmal pneumonia in control group from April2016 to October 2017.The contents of MBP and NSE in the cerebrospinal fluid(CSF)were tested by enzyme linked immunosorbent assay(ELISA). Result The levels of MBP and NSE in the cerebrospinal fluid of the convulsive group and the non-convulsive group were significantly higher than those in control group(P<0.05),and were also higher in convulsive group than non-convulsive group(P<0.05). Conclusion The content of MBP and NSE in CSF can be used as an index to evaluate the central nervous system injury and injury degree of children with mycoplasmal pneumonia complicated with encephalitis,which is helpful for clinicians to predict the condition and make reasonable diagnosis and treatment as soon as possible.

关 键 词：肺炎支原体肺炎 脑炎 髓鞘碱性蛋白 神经元特异性烯醇化酶 

分 类 号：R725.6[医药卫生—儿科]