内皮型一氧化氮合成酶基因多态性与早产儿脑病的相关性研究  

Study on the correlation between endothelial nitric oxide synthase polymorphism and encephalopathy of prematurity

作　　者：常绍鸿[1] 栾斌[2] 张卫星[1] CHANG Shao-hong;LUAN Bin;ZHANG Wei-xing(Department of Pediatrics,Xinxiang Central Hospital,Xinxiang,Henan 453000,China;Department of Pediatrics,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China)

机构地区：[1]新乡市中心医院儿科,河南新乡453000 [2]郑州大学第三附属医院儿科,河南郑州450052

出　　处：《中国儿童保健杂志》2019年第2期205-208,共4页Chinese Journal of Child Health Care

摘　　要：目的研究AGT M235T、ACE I/D、eNOS G894T和eNOS T-786C单核苷酸多态性和早产儿脑病发生的关系,为全面评估患儿病情提供参考。方法选取2014年6月-2017年9月于新乡市中心医院新生儿重症监护室就诊的胎龄<34周的早产儿为研究对象,进行头颅超声和核磁共振影像学检查和基因多态性测定,回顾性分析其临床资料,研究AGT M235T、ACE I/D、eNOS G894T和eNOS T-786C基因多态性和早产儿脑病发生的关系。结果 eNOS T-786C的C等位基因的表达是中重度早产儿脑病的独立危险因素(OR=3.206,95%CI:1.850～7.652)。结论早产儿脑病存在基因易感性,检测eNOS基因多态性有助于评估早产儿预后。Objective To analyze the correlation between endothelial nitric oxide synthase(eNOS)polymorphism(AGT M235 T,ACE I/D,eNOS G894 T,eNOS T-786 C)and encephalopathy of prematurity,in order to provide reference for assessing the patients′condition comprehensively. Methods Preterm infants with gestational age under 34 weeks in neonatal intensive care unit(NICU)of Xinxiang Central Hospital were enrolled in this study from June 2014 to September2017.Head ultrasound and magnetic resonance imaging of the patients were conducted,and gene polymorphisms were tested.Clinical data of the participants were retrospectively collected.The correlation among AGT M235 T,ACE I/D,eNOS G894 T,eNOS T-786 Cand encephalopathy of prematurity was analyzed. Result It was found that eNOS T-786 C TC+CC polymorphism was an independent risk factors for encephalopathy of prematurity(OR=3.206,95%CI:1.850~7.652). Conclusions There is genetic susceptibility in encephalopathy of prematurity.And gene polymorphism test is helpful to assess the prognosis of preterm infants.

关 键 词：基因多态性 早产儿脑病 内皮型一氧化氮合成酶 核磁共振成像 

分 类 号：R722.1[医药卫生—儿科]