野茉莉叶化学成分研究  

Chemical constituents from leaves of Styrax japonicus

作　　者：任杰 潘善庆 赵小芳[1,2] 李日新 陈思 谭诗洁 钟雅倩 李娟 李顺祥[1,2] REN Jie;PAN Shan-qing;ZHAO Xiao-fang;LI Ri-xin;CHEN Si;TAN Shi-jie;ZHONG Ya-qian;LI Juan;LI Shun-xiang(School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Engineering Research Center of Bioactive Substance Discovery of Chinese Medicine,Changsha 410208,China;Drug Safety Evaluation Research Center of Hunan Province,Changsha 410331,China;Chenzhou Wugaishan Tianshi Natural Agricultural Science and Technology Development Co.,Ltd.,Chenzhou 423000,China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湖南省中药活性物质筛选工程技术研究中心,湖南长沙410208 [3]湖南省药物安全评价研究中心,湖南长沙410331 [4]郴州五盖山天时生态农业科技开发有限公司,湖南郴州423000

出　　处：《中草药》2019年第1期30-35,共6页Chinese Traditional and Herbal Drugs

基　　金：国家中医药管理局"药用植物学"重点学科(国中医药发[2009] 30号);湖南省大学生研究性学习和创新性实验计划项目(湘教通[2018] 255号);郴州五盖山天时生态农业科技开发有限公司委托课题(50010103);湖南省高校科技创新团队资助项目(湘教通[2010] 212号);湖南中医药大学中药学一流学科资助项目(校行科字[2018]3号)

摘　　要：目的对野茉莉Styraxjaponicus的叶进行化学成分研究。方法通过硅胶、SephadexLH-20凝胶柱色谱及重结晶等方法进行分离和纯化,根据理化性质、波谱数据进行结构鉴定。结果从野茉莉叶70%乙醇提取物三氯甲烷萃取部位分离得到16个化合物,包括9个苯丙素和7个其他类化合物,分别鉴定为nectandrinB(1)、豆甾醇(2)、荚果蕨素(3)、eupomatenoid-7(4)、β-谷甾醇(5)、去氢二异丁香酚(6)、4-oxo-4[(3β,22E)-stigmasta-5,22-dien-3-yloxy]butanoic acid(7)、4-(3-methory-4-hydroxy)pheny-3-methyl-3-buten-2-one(8)、熊果酸(9)、香草酸(10)、(+)-(7S,8R,8′R)-4,8′-dihydroxy-3-methoxy-1′,2′,3′,4′,5′,6′-hexanorligna-7,7′-lactone (11)、(+)-(7S,8R)-4-hydroxy-3-methoxy-1′,2′,3′,4′,5′,6′,7′-heptanorlign-8′-one(12)、(2S,3R′)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-5-(2-propen-1-yl)-3-benzofuranmethanol(13)、香草醛(14)、对香豆酸(15)和二氢山柰酚(16)。结论化合物1、3～16均为首次从该植物中分离得到。Objective To study the chemical constituents from the leaves of Styrax japonicus. Methods Seventeen compounds including nine phenylpropanoids and seven other constituents were isolated from the chloroform fraction of the 70% ethanol extract of leaves of S. japonicus, using column chromatography over silica gel and Sephadex LH-20 as well as the method of recrystallization. Results On the basis of physical and chemical properties combined with spectral data analysis, their structures were elucidated as nectandrin B(1), stigmasterol(2), matteucinol(3), eupomatenoid-7(4), β-stigmasterol(5), dehydrodiisoeugenol(6), 4-oxo-4[(3β,22 E)-stigmasta-5,22-dien-3-yloxy] butanoic acid(7), 4-(3-methory-4-hydroxy) pheny-3-methyl-3-buten-2-one(8), ursolic acid(9), vanillic acid(10),(+)-(7 S,8 R,8′R)-4,8′-dihydroxy-3-methoxy-1′,2′,3′,4′,5′,6′-hexanorligna-7,7′-lactone(11),(+)-(7 S,8 R)-4-hydroxy-3-methoxy-1′,2′,3′,4′,5′,6′,7′-heptanorlign 8′-one(12),(2 S,3 R′)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-5-(2-propen-1-yl)-3-benzofuranmethanol(13), vanillin(14),(E)-p-coumaric acid(15), and dihydrokaempferol(16). Conclusion Compounds 1, 3-16 are isolated from this plant for the first time.

关 键 词：野茉莉 荚果蕨素 去氢二异丁香酚 熊果酸 香草酸 二氢山柰酚 

分 类 号：R284.1[医药卫生—中药学]