胞磷胆碱钠联合参芎葡萄糖治疗老年高血压性脑梗死的临床效果  

The clinical effect of citicoline sodium combined with Shenxiong glucose in the treatment of senile hypertensive cerebral infarction in the elders

作　　者：周利胜[1] 李杰文 谢伟琼 邓镇强 范国锋 Zhou Lisheng;Li Jiewen;Xie Weiqiong;Deng Zhenqiang;Fan Guofeng(Department of Neurology,Gaoming District People's Hospital,Foshan 528500,China)

机构地区：[1]佛山市高明区人民医院神经内科,528500

出　　处：《中国医师杂志》2019年第1期44-47,共4页Journal of Chinese Physician

基　　金：2017年佛山市自筹经费类科技计划项目(2017AB001084)~~

摘　　要：目的探讨胞磷胆碱钠联合参芎葡萄糖在老年高血压性脑梗死中的临床治疗效果。方法选取2016年1月至2017年12月本院收治的老年高血压性脑梗死患者80例,采用随机数字法将其分为单用组和联用组,每组各40例,两组患者均接受常规治疗,其中单用组患者额外接受参芎葡萄糖注射液100 ml/d静脉滴注治疗,联用组患者额外接受参芎葡萄糖联合胞磷胆碱钠0. 5 g/d静脉滴注治疗,均持续治疗2周。对比分析两组患者治疗前后的炎症因子水平、神经功能缺损评分、认知功能评分以及临床治疗效果。结果经过系统化治疗后,两组患者的血压和血脂控制情况均较治疗前明显好转,但两组之间相比差异无统计学意义(P> 0. 05);两组患者治疗后的血清IL-6,IL-8和TNF-α水平均较治疗前明显降低,而联用组患者炎性因子改善程度明显优于单用组,差异有统计学意义(P <0. 05);治疗后,两组患者氧化应激指标水平均明显改善,MDA含量明显降低,SOD活性和NO含量显著升高,差异均有统计学意义(P <0. 05),且联合组患者的改善程度均明显优于单用组,差异有统计学意义(P <0. 05);经过治疗后,两组患者的MESSS和HDS评分均较治疗前明显改善,而联用组患者改善程度比单用组更明显,差异有统计学意义(P <0. 05);联用组治疗总有效率为92. 5%,明显高于单用组的75. 0%,差异有统计学意义(P <0. 05);两组患者在治疗期间均无明显不良反应发生。结论在常规治疗的基础上联合应用胞磷胆碱钠和参芎葡萄糖治疗老年高血压性脑梗死能够明显降低氧化应激和炎症水平,促进神经功能和认知功能的恢复,提高临床治疗效果且安全性较高,在临床治疗老年高血压性脑梗死中值得推广应用。Objective To investigate the clinical therapeutic effect of citicoline sodium combined with Shenxiong glucose in the treatment of senile hypertensive cerebral infarction in the elders.Methods 80 elderly patients with senile hypertensive cerebral infarctiontreated in our hospital were selected and randomly divided into the single treatment group and the combination treatment group,40 cases in each group. Both groups received the routine treatment.The single treatment group additionally received Shenxiong glucose injection (100 ml/d),while patients in the combination treatment group additionally received Shenqiong glucose injection combined with citicoline sodium intravenous infusion therapy (0.5 g/d),both groups were treated for 2 weeks.The levels of serum inflammatory factors,the neurological deficit score,the cognitive function score were compared and analyzed before and after treatment between two groups.Results After systemic treatment,the blood pressure and blood lipid levels of two groups were significantly improved,but there was no significant difference between the two groups (P >0.05);The serum levels of interleukin (IL)-6,IL-8 and tumor necrosis factor-α (TNF-α)of the combination treatment group improved more significantly (P <0.05).After treatment,the oxidative stress indexes were significantly improved in the two groups (P <0.05).The content of malondialdehyde (MDA)was decreased,while the superoxide dismutase (SOD)activity and nitric oxide (NO)content were increased significantly (P <0.05);and the improvement degree in the combination treatment group was better than in the single treatment group (P <0.05).The degree of improvement in the Modified Edinburgh-Scandinavia Stroke Scale (MESSS)and Hasegawa Dementia Scale (HDS)scores of the combination treatment group was more significant than those in the single treatment group (P <0.05 ).The total effective rate of the combination treatment group was 92.5%,which was significantly higher than that of the single group (75.0%),with statistically significant

关 键 词：高血压 脑梗死 丹参素 川芎嗪 胞苷二磷酸胆碱 老年人 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R544.1[医药卫生—临床医学]