植物环状RNA研究进展  

The Research Advance of Plant Circular RNA

作　　者：高振[1] 骆萌[1] 王磊[1] 宋士任[1] 赵丽萍[1] 许文平[1] 张才喜[1] 王世平[1,2] 马超[1] GAO Zhen;LUO Meng;WANG Lei;SONG Shiren;ZHAO Liping;XU Wenping;ZHANG Caixi;WANG Shiping;MA Chao(School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai 200240,China;Institute of Agro-food Science and Technology/Key Laboratory of Agro-products Processing Technology of Shandong,Shandong Academy of Agricultural Sciences,Ji 'nan 250100,China)

机构地区：[1]上海交通大学农业与生物学院,上海200240 [2]山东省农业科学院农产品研究所/山东省农产品精深加工技术重点实验室,济南250100

出　　处：《园艺学报》2019年第1期171-181,共11页Acta Horticulturae Sinica

基　　金：上海市自然科学基金项目(17ZR1448800);国家现代农业产业技术体系建设专项资金项目(CARS-29-zp-7);上海交通大学晨星-优秀青年学者奖励计划项目(2017)

摘　　要：环状RNA(circularRNA,circRNA)是一类经反向剪接后、由3′末端和5′末端共价结合形成的单链非编码RNA分子,广泛存在于多种生物体中,具有结构稳定、细胞或组织特异性等特征。circRNA具有多种功能,可作为miRNA"海绵"调控miRNA表达;促进来源基因转录;通过与蛋白互作参与相关途径调控等。多种植物circRNA的研究结果暗示其在生物胁迫、非生物胁迫及生长发育中发挥重要作用。对植物circRNA分子特征和作用机制的研究现状进行综述,并结合动物中circRNA的研究进展,讨论植物circRNA的潜在作用机制,并提出植物中尚未解决的问题及其未来的应用前景。Circular RNAs are a class of single-stranded non-coding RNA characterized by the presence of a covalent bond linking the 3′ and 5′ ends generated by backsplicing. Widespread circRNAs were found to be expressed in various organisms. CircRNAs feature stable structure and often show cell-,tissue-,or developmental-stage-specific expression. Some researches showed that circRNAs have been postulated to function as miRNA sponges,to enhance transcription of their host genes,also function as protein decoys and participate in the regulation of pathway. Dramatically increased investigations suggest circRNAs potentially regulate a wide range of biological progresses related to biotic/abiotic responses and plant development. Here,we summarize the features of circRNAs in plant,and their regulatory roles achieved so far. In addition,possible functional mechanism of plant circRNAs is inspired by animals,and the challenges and questions in the research area of plant circRNAs are discussed.

关 键 词：circRNA 非编码RNA 作用机制 生物学功能 

分 类 号：Q752[生物学—分子生物学] Q789