新疆地区维吾尔族、汉族无糖尿病史人群空腹血糖与冠状动脉病变严重程度的关系  

Relationship between fasting plasma glucose and severity of coronary artery disease in Xinjiang Uygur and Han nationality without diabetes history

作　　者：张雷[1] 哈斯达尔.米地里别克 杨玉春[1] 刘江萍 何鹏义[1] 刘志强[1] 木胡牙提.乌拉斯汗 ZHANG Lei;Hasidaer Midilibieke;YANG Yuchun;LIU Jiangping;HE Pengyi;LIU Zhiqiangt;Muhuyati Wulasihan(Heart Internal Medicine Center,The First Affiliated Hospital of Xinjiang Medical University,Xinjiang,Urumqi,830054)

机构地区：[1]新疆医科大学第一附属医院综合心脏内科,乌鲁木齐830011

出　　处：《新疆医学》2018年第10期1056-1059,共4页Xinjiang Medical Journal

摘　　要：目的探讨对新疆维吾尔族(维族)、汉族患者空腹血糖水平与冠状动脉病变严重程度的关系。方法分别将611例维族和763例汉族因高度疑诊冠心病行冠状动脉造影并既往无糖尿病病史的患者纳入本研究。冠状动脉造影示主要冠状动脉或其主要分支直径有≥50%的狭窄既诊断为冠心病(CHD),冠状动脉病变严重程度以Gensini评分表示。根据空腹血糖(FPG)水平将所有研究对象分为:FPG<5.6mmol/L、5.6mmol/L≤FPG<6.1mmol/L、6.1mmol/L≤FPG<7.0mmol/L、FPG≥7.0mmol/L组。对各组人群进行各种生化指标、一般临床资料、冠状动脉造影资料的比较,而且冠状动脉病变严重程度相关的危险因素。结果不同年龄组、性别、吸烟史、高血压病史和空腹血糖组与Gensini评分差异具有统计学意义(P <0.05),汉族、维族两个民族之间Gensini评分差异无统计学意义。其中Gensini评分随着年龄的增加而增加(P <0.001),男性Gensini评分显著高于女性(P<0.001),有吸烟史的Gensini评分显著高于无吸烟史者(P <0.001),有高血压史的Gensini评分显著高于无高血压史者(P <0.001),随着空腹血糖的增加, Gensini评分也有逐渐增加的趋势,差异有统计学意义((P <0.001))。FPG与Gensini评分明显相关((P <0.001))。结论 FPG是冠心病发生以及冠状动脉病变加重的独立危险因素。Objective To investigate the relationship between the level of fasting blood glucose and the prevalence of coronary artery disease in Uygur and Han nationalities in Xinjiang. Methods 611 Uygur patients and 763 Han patients were enrolled in this study because they were highly suspected of coronary artery disease and diagnosed with coronary artery angiography and no history of diabetes mellitus. Coronary artery angiography showed the main coronary artery or its other branches diameter were ≥ 50% and stenosis, it diagnosed as coronary heart disease(CHD), Gensini coronary catheter arteriography score the disease severity. All subjects were classified according to the level of fasting plasma glucose(FPG): FPG <6.0 mmol/L, 5.6 mmol/L≤FPG <6.1 mmol/L, 6.1 mmol/L≤FPG <7.0 mmol/L and FPG≥7.0 mmol/L. All the biochemical indexes, clinical data and coronary artery angiography data were compared, and the risk factors were analyzed related to the severity of coronary artery disease. Results There were significant differences in Gensini score between different age groups, gender, smoking history, hypertension history and fasting blood glucose group(P < 0.05). There was no significant difference in Gensini scores between Han and Uygur nationalities. The Gensini score increased with age(P < 0.001), The male Gensini score was significantly higher than the female(P < 0.001), The Gensini score of patients with smoking history was significantly higher than non-smokers(P < 0.001), The Gensini score was significantly higher in patients with a history of hypertension than the patient without history of hypertension(P < 0.001), when FPG increase, Gensini score also increased gradually, the difference was statistically significant(P < 0.001). FPG and Gensini score was significantly correlated(P < 0.001). Conclusion FPG was an independent risk factor for the prevalence and severity of coronary heart disease.

关 键 词：空腹血糖 冠心病 冠状动脉病变 

分 类 号：R4[医药卫生—临床医学]